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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-7-18
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pubmed:abstractText |
Platycodin D, isolated from the root of Platycodon grandiflorum A. DC. (Campanulaceae) suppressed prostaglandin E2 production at 10 and 30 microM in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA). Platycodin D3 and oleanolic acid showed no effect at these concentrations. Western blot analysis revealed that the induction of COX-2 protein by TPA was inhibited by platycodin D in parallel with the inhibition of prostaglandin E2 production. Platycodin D showed no direct effect on COX-1 and COX-2 activities. TPA-induced release of [3H]arachidonic acid from pre-labeled macrophages was also not inhibited by platycodin D.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oleanolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Triterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/platycodin D
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0032-0943
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11458457-Animals,
pubmed-meshheading:11458457-Arachidonic Acid,
pubmed-meshheading:11458457-Cells, Cultured,
pubmed-meshheading:11458457-Cyclooxygenase 1,
pubmed-meshheading:11458457-Cyclooxygenase 2,
pubmed-meshheading:11458457-Dexamethasone,
pubmed-meshheading:11458457-Dinoprostone,
pubmed-meshheading:11458457-Drugs, Chinese Herbal,
pubmed-meshheading:11458457-Enzyme Induction,
pubmed-meshheading:11458457-Indomethacin,
pubmed-meshheading:11458457-Isoenzymes,
pubmed-meshheading:11458457-Macrophages, Peritoneal,
pubmed-meshheading:11458457-Membrane Proteins,
pubmed-meshheading:11458457-Oleanolic Acid,
pubmed-meshheading:11458457-Plant Roots,
pubmed-meshheading:11458457-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11458457-Protein Kinase C,
pubmed-meshheading:11458457-Rats,
pubmed-meshheading:11458457-Rats, Sprague-Dawley,
pubmed-meshheading:11458457-Saponins,
pubmed-meshheading:11458457-Tetradecanoylphorbol Acetate,
pubmed-meshheading:11458457-Triterpenes
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pubmed:year |
2001
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pubmed:articleTitle |
Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
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pubmed:publicationType |
Letter,
Comparative Study,
Research Support, Non-U.S. Gov't
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