|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0086418,
umls-concept:C0087071,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0376558,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1519697,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1711300,
umls-concept:C2700613
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2001-7-17
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|
pubmed:abstractText |
Telomerase, the enzyme that catalyzes the elongation of telomeres, is illegitimately activated in the majority of cancers, including that of the prostate, where it may greatly extend the life span of malignant cells. The inhibition of telomerase by molecular intervention has been shown to lead eventually to cell death in several tumor or in vitro immortalized cell lines and in 1 case prevent tumor growth in vivo. Therefore, we tested whether a similar strategy may be used to limit the tumorigenic potential of late stage prostate cancer cells.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
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pubmed:issn |
0022-5347
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
166
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
694-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11458119-Animals,
pubmed-meshheading:11458119-Cell Death,
pubmed-meshheading:11458119-Humans,
pubmed-meshheading:11458119-Male,
pubmed-meshheading:11458119-Mice,
pubmed-meshheading:11458119-Mice, Inbred BALB C,
pubmed-meshheading:11458119-Mice, Nude,
pubmed-meshheading:11458119-Neoplasm Transplantation,
pubmed-meshheading:11458119-Prostatic Neoplasms,
pubmed-meshheading:11458119-Telomerase,
pubmed-meshheading:11458119-Tumor Cells, Cultured
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pubmed:year |
2001
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|
pubmed:articleTitle |
Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells.
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pubmed:affiliation |
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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