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11457589

Source:http://linkedlifedata.com/resource/pubmed/id/11457589

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pubmed-article:11457589pubmed:abstractTextAlthough glycine receptors are widely expressed in the forebrain their function is obscure. We studied their activation by two possible endogenous ligands, glycine and taurine, and demonstrate a different expression pattern of glycine receptors in neostriatal cholinergic interneurons from two rodent species. Single-cell-reverse transcription-polymerase chain reaction analysis of glycine receptor-subunit expression was combined with whole-cell recordings from acutely isolated cholinergic interneurons. All cells expressed the alpha2-glycine receptor subunit, the majority (72%) in mice but none in young and aged rats expressed the alpha3-subunit. The beta-subunit expression was associated with both a higher efficacy and a higher potency of the partial agonist taurine. Cells expressing the alpha3-subunit displayed a slower desensitization of taurine responses than of glycine responses, in contrast to cells expressing the alpha2-, beta-subunits where desensitization time constants were similar. Glycine responses were reduced by preapplication of taurine; this effect was more pronounced in cells lacking the alpha3-subunit. We demonstrate interspecies differences and heterogeneity in expression and function of glycine receptors within the same neuronal population in the neostriatum.lld:pubmed
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pubmed-article:11457589pubmed:authorpubmed-author:HaasH LHLlld:pubmed
pubmed-article:11457589pubmed:authorpubmed-author:SergeevaO AOAlld:pubmed
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pubmed-article:11457589pubmed:dateRevised2009-11-3lld:pubmed
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pubmed-article:11457589pubmed:articleTitleExpression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse.lld:pubmed
pubmed-article:11457589pubmed:affiliationDepartment of Neurophysiology, Heinrich-Heine-Universität, D-40001 Düsseldorf, Germany. olga.sergeeva@uni-duesseldorf.delld:pubmed
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