Source:http://linkedlifedata.com/resource/pubmed/id/11457589
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-7-17
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| pubmed:abstractText |
Although glycine receptors are widely expressed in the forebrain their function is obscure. We studied their activation by two possible endogenous ligands, glycine and taurine, and demonstrate a different expression pattern of glycine receptors in neostriatal cholinergic interneurons from two rodent species. Single-cell-reverse transcription-polymerase chain reaction analysis of glycine receptor-subunit expression was combined with whole-cell recordings from acutely isolated cholinergic interneurons. All cells expressed the alpha2-glycine receptor subunit, the majority (72%) in mice but none in young and aged rats expressed the alpha3-subunit. The beta-subunit expression was associated with both a higher efficacy and a higher potency of the partial agonist taurine. Cells expressing the alpha3-subunit displayed a slower desensitization of taurine responses than of glycine responses, in contrast to cells expressing the alpha2-, beta-subunits where desensitization time constants were similar. Glycine responses were reduced by preapplication of taurine; this effect was more pronounced in cells lacking the alpha3-subunit. We demonstrate interspecies differences and heterogeneity in expression and function of glycine receptors within the same neuronal population in the neostriatum.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Strychnine,
http://linkedlifedata.com/resource/pubmed/chemical/Taurine
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0306-4522
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
104
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1043-55
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| pubmed:dateRevised |
2009-11-3
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| pubmed:meshHeading |
pubmed-meshheading:11457589-Acetylcholine,
pubmed-meshheading:11457589-Aging,
pubmed-meshheading:11457589-Animals,
pubmed-meshheading:11457589-Cell Size,
pubmed-meshheading:11457589-Chloride Channels,
pubmed-meshheading:11457589-Dose-Response Relationship, Drug,
pubmed-meshheading:11457589-Gene Expression,
pubmed-meshheading:11457589-Glycine,
pubmed-meshheading:11457589-Glycine Agents,
pubmed-meshheading:11457589-Interneurons,
pubmed-meshheading:11457589-Mice,
pubmed-meshheading:11457589-Mice, Inbred C57BL,
pubmed-meshheading:11457589-Neostriatum,
pubmed-meshheading:11457589-Patch-Clamp Techniques,
pubmed-meshheading:11457589-RNA, Messenger,
pubmed-meshheading:11457589-Rats,
pubmed-meshheading:11457589-Rats, Wistar,
pubmed-meshheading:11457589-Receptors, Glycine,
pubmed-meshheading:11457589-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11457589-Strychnine,
pubmed-meshheading:11457589-Taurine
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| pubmed:year |
2001
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| pubmed:articleTitle |
Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse.
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| pubmed:affiliation |
Department of Neurophysiology, Heinrich-Heine-Universität, D-40001 Düsseldorf, Germany. olga.sergeeva@uni-duesseldorf.de
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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