Linked Life Data

11455895

Source:http://linkedlifedata.com/resource/pubmed/id/11455895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-7-17
pubmed:abstractText
In order to study rapid changes in 15-ketodihydro-PGF2 alpha, cortisol and progesterone in the period preceding parturition in cattle, pre-term parturition was induced in 4 late pregnant heifers. Parturitions were induced by 2 intramuscular injections of 20 mg dexamethasone with a 24-h interval. The first injection was made on days 254, 258, 264 and 265 in gestation, respectively. Twenty-four h before the first injection an intravenous polyurethane cannula was inserted. Blood samples were collected at least every hour until 12 h after parturition and during the second stage of labour at least 6 times per hour. Plasma was analysed for 15-ketodihydro-PGF2 alpha and progesterone by radioimmunoassays, and for cortisol by an ELISA. The average time from injection to parturition was 7.7 (6.6-8.9) days (mean (range)). Two of the heifers had retained foetal membranes (RFM). At the start of the experiment the levels of PGF2 alpha metabolite were low (< 300 pmol/L) and increased slowly to levels between 1000 and 2000 pmol/L at one day before parturition. During the last day, however, the levels increased rapidly and the highest levels (> 10,000 pmol/L) were reached at the time of delivery. No pulsatile release was seen. Immediately after foetal expulsion the PG-metabolite levels decreased rapidly in all animals. In the 2 animals with RFM, however, this decline ceased within a few h. The PG-metabolite levels in these animals then started to increase and reached levels as high as during parturition. Luteolysis occurred between 1.6 and 0.4 days before parturition in all animals. The cortisol profile showed a distinct peak at the time of parturition in the RFM heifers. This peak was absent in the non-RFM heifers. This study shows that the PGF2 alpha release at prepartal luteolysis and parturition is not pulsatile in cattle and that cortisol profiles in heifers with retained foetal membranes might differ from the profiles in non-RFM heifers at the time of parturition.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-10221982, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-10411520, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-10907837, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-1172518, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-1287952, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-2267714, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-6957702, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-7344538, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-8365354, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-8633808, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-878966, http://linkedlifedata.com/resource/pubmed/commentcorrection/11455895-9854179
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-605X
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
15-ketodihydro-PGF2 alpha, progesterone and cortisol profiles in heifers after induction of parturition by injection of dexamethasone.
pubmed:affiliation
Department of Obstetrics and Gynaecology, Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, Uppsala, Sweden. kristian.konigsson@og.slu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't