| pubmed-article:11455203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C0029205 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:11455203 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:11455203 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11455203 | pubmed:dateCreated | 2001-7-16 | lld:pubmed |
| pubmed-article:11455203 | pubmed:abstractText | Ca2+ inflow via store-operated Ca2+ channels was investigated in rings of rat tail and basilar arteries kept in serum-free organ culture, which is known to preserve the contractility of the vascular smooth muscle. After culture for 3-4 days, Ca2+ release from intracellular stores in response to caffeine (20 mM) was augmented 2- to 4-fold. Following depletion of intracellular Ca2+ stores by caffeine and thapsigargin (10 microM), addition of Ca2+ (2.5 mM) caused an increase in the intracellular Ca2+ concentration which was 2-3 times greater in cultured than in freshly dissected rings, and was not affected by verapamil (10 microM). In contrast, L-type Ca2+ channel currents were decreased by 20% after culture. While freshly dissected rings developed no or very little force in response to the addition of Ca2+ after store depletion, cultured rings developed 42% (tail artery) and 60% (basilar artery) of the force of high-K+-induced contractions. These contractions in cultured vessels were insensitive to verapamil but could be completely relaxed by SKF-96365 (30 microM). Store depletion by caffeine increased the Mn2+ quench rate 3- to 4-fold in freshly dissected as well as cultured tail artery, while there was no increase in freshly dissected basilar artery, but a 3-fold increase in cultured basilar artery. Uptake of Ca2+ into intracellular stores was twice as rapid in cultured as in freshly dissected tail artery. This study shows that organ culture of vascular smooth muscle tissue causes changes in Ca2+ handling, resembling the pattern seen in dedifferentiating smooth muscle cells in culture, although contractile properties are maintained. | lld:pubmed |
| pubmed-article:11455203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11455203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11455203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11455203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11455203 | pubmed:issn | 1018-1172 | lld:pubmed |
| pubmed-article:11455203 | pubmed:author | pubmed-author:HellstrandPP | lld:pubmed |
| pubmed-article:11455203 | pubmed:author | pubmed-author:BergdahlAA | lld:pubmed |
| pubmed-article:11455203 | pubmed:author | pubmed-author:DreisDD | lld:pubmed |
| pubmed-article:11455203 | pubmed:copyrightInfo | Copyright 2001 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:11455203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11455203 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:11455203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11455203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11455203 | pubmed:pagination | 324-31 | lld:pubmed |
| pubmed-article:11455203 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11455203 | pubmed:articleTitle | Increased store-operated Ca2+ entry into contractile vascular smooth muscle following organ culture. | lld:pubmed |
| pubmed-article:11455203 | pubmed:affiliation | Department of Physiological Sciences, Lund University, Lund, Sweden. | lld:pubmed |
| pubmed-article:11455203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11455203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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