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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-7-20
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pubmed:databankReference |
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pubmed:abstractText |
Synaptic vesicle biogenesis involves the recycling of synaptic vesicle components by clathrin-mediated endocytosis from the presynaptic membrane. stoned B, a protein encoded by the stoned locus in Drosophila melanogaster has been shown to regulate vesicle recycling by interacting with synaptotagmin. We report here the identification and characterization of a human homolog of stoned B (hStnB). Human stoned B is a brain-specific protein which co-enriches with other endocytic proteins such as AP-2 in a crude synaptic vesicle fraction and at nerve terminals. A domain with homology to the medium chain of adaptor complexes binds directly to both AP-2 and synaptotagmin and competes with AP-2 for the same binding site within synaptotagmin. Finally we show that the mu 2 homology domain of hStnB stimulates the uncoating of both clathrin and AP-2 adaptors from clathrin-coated vesicles. We hypothesize that hStnB regulates synaptic vesicle recycling by facilitating vesicle uncoating.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10352010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10364223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10407025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10455054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10459011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10490020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10535736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10611977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10677033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10851177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10931870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-10966473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11069931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11080148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11146663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11148137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11160392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11175756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-11222632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-4348786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-7877694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-8087843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-8524399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9674434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9693377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9714795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9812899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9822725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454741-9830048
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptotagmins,
http://linkedlifedata.com/resource/pubmed/chemical/stoned B protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
634-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11454741-Humans,
pubmed-meshheading:11454741-Animals,
pubmed-meshheading:11454741-Drosophila,
pubmed-meshheading:11454741-Rats,
pubmed-meshheading:11454741-Brain Chemistry,
pubmed-meshheading:11454741-Microscopy, Fluorescence,
pubmed-meshheading:11454741-Enzyme Inhibitors,
pubmed-meshheading:11454741-Membrane Proteins,
pubmed-meshheading:11454741-Nerve Tissue Proteins,
pubmed-meshheading:11454741-Amino Acid Sequence,
pubmed-meshheading:11454741-Protein Binding,
pubmed-meshheading:11454741-Tissue Distribution,
pubmed-meshheading:11454741-Binding Sites,
pubmed-meshheading:11454741-Cell Fractionation,
pubmed-meshheading:11454741-Molecular Sequence Data,
pubmed-meshheading:11454741-Carrier Proteins,
pubmed-meshheading:11454741-Protein Structure, Tertiary,
pubmed-meshheading:11454741-Sequence Alignment,
pubmed-meshheading:11454741-Drosophila Proteins,
pubmed-meshheading:11454741-Membrane Glycoproteins,
pubmed-meshheading:11454741-Calcium-Binding Proteins,
pubmed-meshheading:11454741-Recombinant Fusion Proteins,
pubmed-meshheading:11454741-Immunoblotting,
pubmed-meshheading:11454741-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:11454741-Synaptotagmins,
pubmed-meshheading:11454741-Genes, Reporter,
pubmed-meshheading:11454741-Clathrin-Coated Vesicles
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