11454472

Source:http://linkedlifedata.com/resource/pubmed/id/11454472

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205250, umls-concept:C0220781, umls-concept:C0243192, umls-concept:C1707689, umls-concept:C1883254
pubmed:issue	15
pubmed:dateCreated	2001-7-16
pubmed:abstractText	EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Alprostadil, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclobutanes, http://linkedlifedata.com/resource/pubmed/chemical/Cyclopentanes, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/PTGER2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP2..., http://linkedlifedata.com/resource/pubmed/chemical/butaprost
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0960-894X
pubmed:author	pubmed-author:EgashiraHH, pubmed-author:HaradaHH, pubmed-author:IshidaAA, pubmed-author:KondoKK, pubmed-author:MaruyamaTT, pubmed-author:NaganawaAA, pubmed-author:NakaiHH, pubmed-author:OgawaMM, pubmed-author:OhuchidaSS, pubmed-author:SagawaKK, pubmed-author:TaneGG, pubmed-author:TodaMM
pubmed:issnType	Print
pubmed:day	6
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2025-8
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:11454472-Alprostadil, pubmed-meshheading:11454472-Animals, pubmed-meshheading:11454472-Binding Sites, pubmed-meshheading:11454472-CHO Cells, pubmed-meshheading:11454472-Cricetinae, pubmed-meshheading:11454472-Cyclic AMP, pubmed-meshheading:11454472-Cyclobutanes, pubmed-meshheading:11454472-Cyclopentanes, pubmed-meshheading:11454472-Dinoprostone, pubmed-meshheading:11454472-Drug Design, pubmed-meshheading:11454472-Female, pubmed-meshheading:11454472-Humans, pubmed-meshheading:11454472-Ligands, pubmed-meshheading:11454472-Mice, pubmed-meshheading:11454472-Rats, pubmed-meshheading:11454472-Receptors, Prostaglandin E, pubmed-meshheading:11454472-Receptors, Prostaglandin E, EP2 Subtype, pubmed-meshheading:11454472-Sensitivity and Specificity, pubmed-meshheading:11454472-Uterine Contraction
pubmed:year	2001
pubmed:articleTitle	Design and synthesis of a highly selective EP2-receptor agonist.
pubmed:affiliation	Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan. k.tani@ono.co.jp
pubmed:publicationType	Journal Article