| pubmed-article:11454067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11454067 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:11454067 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11454067 | pubmed:dateCreated | 2001-7-16 | lld:pubmed |
| pubmed-article:11454067 | pubmed:abstractText | We investigated the role of interleukin-6 (IL-6) in the development of the immune response to a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis emulsified in the adjuvant dimethyldioctadecylammonium bromide (DDA). C57Bl/6 mice immunized with this vaccine developed a strong T helper 1 (Th1) response characterized by an increased production of interferon-gamma (IFN-gamma) secreted by CD4+ T cells. Neutralization of IL-6 during in vivo priming resulted in marked reduction in the ability of T cells to secrete IFN-gamma and IL-2 and to proliferate. IL-6 gene-disrupted mice primed with the vaccine showed a decrease in the number of IFN-gamma-producing cells and an increase in IL-4-secreting cells as compared to control mice. In contrast, neutralization of IL-6 during a boost of the vaccine in previously primed mice did not affect the development of IFN-gamma-producing cells but still increased the number of IL-4-producing cells. Our work shows that IL-6 plays a major role in the priming but not in the later expression of a Th1 response to a tuberculosis vaccine. | lld:pubmed |
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| pubmed-article:11454067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11454067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11454067 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11454067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11454067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11454067 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11454067 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:11454067 | pubmed:author | pubmed-author:AndersenPP | lld:pubmed |
| pubmed-article:11454067 | pubmed:author | pubmed-author:AppelbergRR | lld:pubmed |
| pubmed-article:11454067 | pubmed:author | pubmed-author:FlóridoMM | lld:pubmed |
| pubmed-article:11454067 | pubmed:author | pubmed-author:MOIRR ARA | lld:pubmed |
| pubmed-article:11454067 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11454067 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:11454067 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11454067 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11454067 | pubmed:pagination | 375-81 | lld:pubmed |
| pubmed-article:11454067 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11454067 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11454067 | pubmed:articleTitle | Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine. | lld:pubmed |
| pubmed-article:11454067 | pubmed:affiliation | Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal. | lld:pubmed |
| pubmed-article:11454067 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11454067 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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