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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-7-16
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pubmed:abstractText |
We investigated the role of interleukin-6 (IL-6) in the development of the immune response to a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis emulsified in the adjuvant dimethyldioctadecylammonium bromide (DDA). C57Bl/6 mice immunized with this vaccine developed a strong T helper 1 (Th1) response characterized by an increased production of interferon-gamma (IFN-gamma) secreted by CD4+ T cells. Neutralization of IL-6 during in vivo priming resulted in marked reduction in the ability of T cells to secrete IFN-gamma and IL-2 and to proliferate. IL-6 gene-disrupted mice primed with the vaccine showed a decrease in the number of IFN-gamma-producing cells and an increase in IL-4-secreting cells as compared to control mice. In contrast, neutralization of IL-6 during a boost of the vaccine in previously primed mice did not affect the development of IFN-gamma-producing cells but still increased the number of IL-4-producing cells. Our work shows that IL-6 plays a major role in the priming but not in the later expression of a Th1 response to a tuberculosis vaccine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10087647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10427995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10531224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10580801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10679078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10742553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-10816480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-1328464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-1385868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-1398949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-1900811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-2117636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-2147202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-2523712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-2652252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7547713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7595206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7790102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7904900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7910595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-7959868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8097338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8127368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8188380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8189056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8376777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8871652,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-8977207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9009322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9029090,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9218573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9353074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9485207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9509669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9529145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9597139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9653168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9780277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11454067-9811895
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11454067-Animals,
pubmed-meshheading:11454067-Antibodies, Monoclonal,
pubmed-meshheading:11454067-BCG Vaccine,
pubmed-meshheading:11454067-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11454067-Cell Culture Techniques,
pubmed-meshheading:11454067-Cell Division,
pubmed-meshheading:11454067-Female,
pubmed-meshheading:11454067-Immunization, Secondary,
pubmed-meshheading:11454067-Interferon-gamma,
pubmed-meshheading:11454067-Interleukin-2,
pubmed-meshheading:11454067-Interleukin-4,
pubmed-meshheading:11454067-Interleukin-6,
pubmed-meshheading:11454067-Lymphocyte Activation,
pubmed-meshheading:11454067-Male,
pubmed-meshheading:11454067-Mice,
pubmed-meshheading:11454067-Mice, Inbred C57BL,
pubmed-meshheading:11454067-Th1 Cells,
pubmed-meshheading:11454067-Vaccination
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pubmed:year |
2001
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pubmed:articleTitle |
Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine.
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pubmed:affiliation |
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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