Linked Life Data

11453308

Source:http://linkedlifedata.com/resource/pubmed/id/11453308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2001-7-16
pubmed:abstractText
Individual risk of toxicity or cancer can be affected by one's exposure to sufficiently high doses of particular environmental agents (or mixtures), combined with each person's underlying genetic predisposition. The development of unequivocal DNA tests for genetic susceptibility to toxicity and cancer and the identification of individuals at increased risk, would revolutionize the fields of public health and preventive medicine. A growing number of human genetic polymorphisms in drug-metabolizing enzymes (DMEs) and the receptors controlling DME expression, are being characterized, some of these have been shown to be correlated with risk of toxicity or cancer, whereas, others presently remain equivocal and require further study. 'Phase I' DMEs, many of which represent cytochromes P450, sometimes metabolically activate pro-carcinogens to genotoxic electrophilic intermediates and other times are involved in detoxification. 'Phase II' DMEs are sometimes activating, but usually they conjugate Phase I intermediates to water-soluble derivatives, to complete the detoxification cycle. Genetic differences in the regulation, expression and activity of genes coding for Phase I and Phase II DMEs and DME receptors that control DME activity levels, can be crucial factors in defining cancer susceptibility and the toxic or carcinogenic power of environmental chemicals. In this review, our current knowledge about polymorphisms in several of these genes is summarized.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0048-9697
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
274
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-102
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer.
pubmed:affiliation
Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, OH 45267-0056, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.