Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-7-13
pubmed:abstractText
The antioxidant activity of capsaicin (CAP) was measured in the oxidation of methyl linoleate (ML) in homogeneous solution, of ML micelles in aqueous dispersions and also of soybean phosphatidylcholine liposomal membrane, and was compared to that of alpha-tocopherol (alpha-TOH) which is one of the most important antioxidants in vivo. The reactivity of CAP toward galvinoxyl (a model phenoxyl radical) in acetonitrile solution was found to be much smaller than that of alpha-TOH, suggesting that the radical scavenging activity of CAP is much weaker than that of alpha-TOH. In fact, in homogeneous acetonitrile solution where the antioxidant activity is determined primarily by the chemical activity of the antioxidant toward peroxyl radicals, CAP inhibited the oxidation of ML much less efficiently than alpha-TOH and a clear induction period was not observed. The antioxidant activity of CAP was found to be about 60 times smaller than that of alpha-TOH in homogeneous solution. However, in micelle oxidation, the difference in antioxidant activity of the two antioxidants was much smaller than in homogeneous solution. Furthermore, in the membrane, CAP inhibited the oxidation almost as effectively as alpha-TOH. These results suggest that CAP can act as an antioxidant in the biomembrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2,2'-azobis(2,4-dimethylvaleronitril..., http://linkedlifedata.com/resource/pubmed/chemical/Acetonitriles, http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Azo Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Benzhydryl Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin, http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers, http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Liposomes, http://linkedlifedata.com/resource/pubmed/chemical/Membranes, Artificial, http://linkedlifedata.com/resource/pubmed/chemical/Micelles, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Peroxides, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines, http://linkedlifedata.com/resource/pubmed/chemical/Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Solvents, http://linkedlifedata.com/resource/pubmed/chemical/acetonitrile, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol, http://linkedlifedata.com/resource/pubmed/chemical/galvinoxyl, http://linkedlifedata.com/resource/pubmed/chemical/methyl linoleate, http://linkedlifedata.com/resource/pubmed/chemical/perhydroxyl radical
pubmed:status
MEDLINE
pubmed:issn
1351-0002
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11450982-Acetonitriles, pubmed-meshheading:11450982-Antioxidants, pubmed-meshheading:11450982-Azo Compounds, pubmed-meshheading:11450982-Benzhydryl Compounds, pubmed-meshheading:11450982-Capsaicin, pubmed-meshheading:11450982-Free Radical Scavengers, pubmed-meshheading:11450982-Kinetics, pubmed-meshheading:11450982-Linoleic Acids, pubmed-meshheading:11450982-Lipid Peroxidation, pubmed-meshheading:11450982-Liposomes, pubmed-meshheading:11450982-Membranes, Artificial, pubmed-meshheading:11450982-Micelles, pubmed-meshheading:11450982-Nitriles, pubmed-meshheading:11450982-Oxidation-Reduction, pubmed-meshheading:11450982-Peroxides, pubmed-meshheading:11450982-Phosphatidylcholines, pubmed-meshheading:11450982-Solutions, pubmed-meshheading:11450982-Solvents, pubmed-meshheading:11450982-Spices, pubmed-meshheading:11450982-alpha-Tocopherol
pubmed:year
2001
pubmed:articleTitle
Antioxidant effect of capsaicin on lipid peroxidation in homogeneous solution, micelle dispersions and liposomal membranes.
pubmed:affiliation
School of Health Sciences, Kyorin University, Hachioji, Tokyo, Japan.
pubmed:publicationType
Journal Article, Comparative Study