Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-7-12
pubmed:abstractText
Antiangiogenesis drugs can be difficult to evaluate because they produce disease stabilization rather than tumor regression. Markers of endothelial mass in tumors may be of value to monitor therapy and evaluate such drugs. Soluble domains of the endothelial receptor tyrosine kinases, sTie2 (angiopoietin receptor) and sFlt1 (vascular endothelial growth factor receptor-1) were analyzed by sandwich ELISA in serum samples from 43 patients with advanced renal cancer before and 1 month after antiangiogenic therapy with razoxane. Pretreatment sFlt1 levels were 0.77 ng/ml +/- 0.48 (SD) and sTie2 74.3 ng/ml +/- 15 (SD). Pretreatment sFlt1 levels above the median were associated with a lesser chance of stable disease (P = 0.04) and poorer survival (P = 0.01). Fall of sTie2 on treatment was associated with stable disease (P = 0.05) and improved survival (P = 0.04). The soluble receptors measured weeks before response were assessed and correlated with response and survival, showing they may be useful to monitor and develop antiangiogenic therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1992-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11448916-Antineoplastic Agents, pubmed-meshheading:11448916-Binding Sites, pubmed-meshheading:11448916-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:11448916-Female, pubmed-meshheading:11448916-Humans, pubmed-meshheading:11448916-Kidney Neoplasms, pubmed-meshheading:11448916-Male, pubmed-meshheading:11448916-Middle Aged, pubmed-meshheading:11448916-Multivariate Analysis, pubmed-meshheading:11448916-Neovascularization, Pathologic, pubmed-meshheading:11448916-Prognosis, pubmed-meshheading:11448916-Proto-Oncogene Proteins, pubmed-meshheading:11448916-Razoxane, pubmed-meshheading:11448916-Receptor, TIE-2, pubmed-meshheading:11448916-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:11448916-Solubility, pubmed-meshheading:11448916-Survival Analysis, pubmed-meshheading:11448916-Treatment Outcome, pubmed-meshheading:11448916-Vascular Endothelial Growth Factor Receptor-1
pubmed:year
2001
pubmed:articleTitle
Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy.
pubmed:affiliation
Imperial Cancer Research Fund, Molecular Oncology Laboratories, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. aharris.lab@icrf.icnet.uk
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial