|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2001-7-12
|
|
pubmed:abstractText |
Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and induces anterior development by antagonizing Wnt signaling. Although several families of secreted antagonists have been shown to inhibit Wnt signal transduction by binding to Wnt, the molecular mechanism of Dkk-1 action is unknown. The Wnt family of secreted growth factors initiates signaling via the Frizzled (Fz) receptor and its candidate coreceptor, LDL receptor-related protein 6 (LRP6), presumably through Fz-LRP6 complex formation induced by Wnt. The significance of the Fz-LRP6 complex in signal transduction remains to be established.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DKK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/LDL-Receptor Related Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LRP5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/LRP6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-catenin protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/dkk1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/dkk1 protein, zebrafish
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0960-9822
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
951-61
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11448771-Animals,
pubmed-meshheading:11448771-Cell Line,
pubmed-meshheading:11448771-Cytoskeletal Proteins,
pubmed-meshheading:11448771-Frizzled Receptors,
pubmed-meshheading:11448771-Humans,
pubmed-meshheading:11448771-Immunoblotting,
pubmed-meshheading:11448771-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11448771-LDL-Receptor Related Proteins,
pubmed-meshheading:11448771-Ligands,
pubmed-meshheading:11448771-Low Density Lipoprotein Receptor-Related Protein-5,
pubmed-meshheading:11448771-Low Density Lipoprotein Receptor-Related Protein-6,
pubmed-meshheading:11448771-Microinjections,
pubmed-meshheading:11448771-Models, Biological,
pubmed-meshheading:11448771-Oocytes,
pubmed-meshheading:11448771-Precipitin Tests,
pubmed-meshheading:11448771-Protein Binding,
pubmed-meshheading:11448771-Proteins,
pubmed-meshheading:11448771-Proto-Oncogene Proteins,
pubmed-meshheading:11448771-RNA,
pubmed-meshheading:11448771-Receptors, LDL,
pubmed-meshheading:11448771-Recombinant Proteins,
pubmed-meshheading:11448771-Signal Transduction,
pubmed-meshheading:11448771-Trans-Activators,
pubmed-meshheading:11448771-Wnt Proteins,
pubmed-meshheading:11448771-Xenopus Proteins,
pubmed-meshheading:11448771-Xenopus laevis,
pubmed-meshheading:11448771-Zebrafish Proteins,
pubmed-meshheading:11448771-beta Catenin
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
|
|
pubmed:affiliation |
Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
