Linked Life Data

11447143

Source:http://linkedlifedata.com/resource/pubmed/id/11447143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2001-7-11
pubmed:databankReference
pubmed:abstractText
The acquisition of immunity following subclinical or resolved infection with the intracellular parasite Leishmania donovani suggests that vaccination could prevent visceral leishmaniasis (VL). The LACK (Leishmania homolog of receptors for activated C kinase) antigen is of interest as a vaccine candidate for the leishmaniases because of its immunopathogenic role in murine L. major infection. Immunization of mice with a truncated (24-kDa) version of the 36-kDa LACK antigen, delivered in either protein or DNA form, was found previously to protect against cutaneous L. major infection by redirecting the early T-cell response away from a pathogenic interleukin-4 (IL-4) response and toward a protective Th1 response. The amino acid sequence of the Leishmania p36(LACK) antigen is highly conserved, but the efficacy of this vaccine antigen in preventing disease caused by strains other than L. major has not been determined. We investigated the efficacy of a p36(LACK) DNA vaccine against VL because of the serious nature of this form of leishmaniasis and because it was unclear whether the LACK vaccine would be effective in a model where there was not a dominant pathogenic IL-4 response. We demonstrate here that although the LACK DNA vaccine induced a robust parasite-specific Th1 immune response (IFN-gamma but not IL-4 production) and primed for an in vivo T-cell response to inoculated parasites, it did not induce protection against cutaneous or systemic L. donovani challenge. Coadministration of IL-12 DNA with the vaccine did not enhance the strong vaccine-induced Th1 response or augment a protective effect.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10072541, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10092078, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10190902, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10377151, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10415048, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10418902, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10580198, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10670653, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10759774, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-10992459, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-11027804, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-11119512, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-11120835, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-1695670, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-1901883, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-2231712, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-2295807, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-2295814, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-2522103, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-3131421, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-3182080, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-3782864, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-4225002, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7086136, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7275314, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7591056, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7591152, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7725103, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7729921, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7750991, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-7904381, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-8265576, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-8450215, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-8666803, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-8832890, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9035103, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9120289, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9175832, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9314562, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9423834, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9551925, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9558102, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9632596, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9747459, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9796067, http://linkedlifedata.com/resource/pubmed/commentcorrection/11447143-9846579
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4719-25
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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