Source:http://linkedlifedata.com/resource/pubmed/id/11446495
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2001-7-11
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| pubmed:abstractText |
This study assessed the contribution of polymorphisms of angiotensin II (AngII) receptors and bradykinin B2 (BK-B2) receptor to hypertension and acute myocardial infarction (AMI) in a Japanese population: 150 subjects with essential hypertension, 150 subjects with AMI with/without hypertension, and 150 healthy, age- and sex-matched controls. Polymorphisms of the AngII type 1 receptor (1166 A/C) and type 2 receptor (3123 C/A), and the BK-B2 receptor (-58T/C, exon 1) were analyzed and significant differences of genotypes and allelic frequencies in the AngII type 2 receptor C/A and BK-B2 receptor -58T/C were found between the essential hypertension and control subjects. Further, a significantly higher incidence of the C allele of the BK-B2 receptor was seen in AMI subjects with hypertension compared with those without hypertension. Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0047-1828
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
621-6
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11446495-Adult,
pubmed-meshheading:11446495-Aged,
pubmed-meshheading:11446495-Case-Control Studies,
pubmed-meshheading:11446495-Female,
pubmed-meshheading:11446495-Gene Frequency,
pubmed-meshheading:11446495-Genetic Predisposition to Disease,
pubmed-meshheading:11446495-Genotype,
pubmed-meshheading:11446495-Humans,
pubmed-meshheading:11446495-Hypertension,
pubmed-meshheading:11446495-Male,
pubmed-meshheading:11446495-Middle Aged,
pubmed-meshheading:11446495-Myocardial Infarction,
pubmed-meshheading:11446495-Polymorphism, Genetic,
pubmed-meshheading:11446495-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:11446495-Receptor, Bradykinin B2,
pubmed-meshheading:11446495-Receptors, Angiotensin,
pubmed-meshheading:11446495-Receptors, Bradykinin,
pubmed-meshheading:11446495-Retrospective Studies
|
| pubmed:year |
2001
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| pubmed:articleTitle |
The genetic factor in acute myocardial infarction with hypertension.
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| pubmed:affiliation |
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article
|