|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-7-10
|
|
pubmed:abstractText |
The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0028-3878
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
127-30
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11445641-Aged,
pubmed-meshheading:11445641-Atrophy,
pubmed-meshheading:11445641-Brain,
pubmed-meshheading:11445641-Brain Diseases,
pubmed-meshheading:11445641-Fragile X Mental Retardation Protein,
pubmed-meshheading:11445641-Fragile X Syndrome,
pubmed-meshheading:11445641-Heterozygote,
pubmed-meshheading:11445641-Humans,
pubmed-meshheading:11445641-Magnetic Resonance Imaging,
pubmed-meshheading:11445641-Male,
pubmed-meshheading:11445641-Middle Aged,
pubmed-meshheading:11445641-Motivation,
pubmed-meshheading:11445641-Nerve Tissue Proteins,
pubmed-meshheading:11445641-Parkinsonian Disorders,
pubmed-meshheading:11445641-RNA, Messenger,
pubmed-meshheading:11445641-RNA-Binding Proteins,
pubmed-meshheading:11445641-Tremor
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.
|
|
pubmed:affiliation |
M.I.N.D. Institute and the University of California at Davis Medical Center, Sacramento 95817, USA. randi.hagerman@ucdmc.udavis.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|
