Source:http://linkedlifedata.com/resource/pubmed/id/11443535
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-7-9
|
| pubmed:databankReference | |
| pubmed:abstractText |
The cholecystokinin gene (CCK) is thought to play a role in the pathogenesis of both panic disorder and schizophrenia. In this study, we have extended the 5'-upstream sequence of the CCK gene, and identified a compound short tandem repeat (STR), located approximately -2.2 to -1.8 kb from the cap site. This STR was found to be polymorphic with ten different allele lengths. Case-control studies using 73 panic patients, 305 schizophrenics and 252 controls showed a significant allelic association with panic disorder (P = 0.025), but not with schizophrenia. Dividing the STR alleles into three classes according to length, Long (L), Medium (M) and Short (S), produced strong genotypic (MM) (nominal P = 0.0014) and allelic (M) (nominal P = 0.0079) associations with panic disorder. screening the newly extended promoter region detected not only the previously identified -36c>t and -188a>g single nucleotide polymorphisms (SNPs) but a new rare snp, -345g>C. Neither of the former two SNPs showed significant association with either panic disorder or schizophrenia. Haplotypic distributions of the STR and SNPs -188 and -36 were significantly different between panic samples and controls (P = 0.0003). These findings suggest that the novel STR or a nearby variant may confer susceptibility to the development of panic disorder.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1359-4184
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
465-70
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11443535-5' Untranslated Regions,
pubmed-meshheading:11443535-Adolescent,
pubmed-meshheading:11443535-Adult,
pubmed-meshheading:11443535-Aged,
pubmed-meshheading:11443535-Aged, 80 and over,
pubmed-meshheading:11443535-Alleles,
pubmed-meshheading:11443535-Base Sequence,
pubmed-meshheading:11443535-Cholecystokinin,
pubmed-meshheading:11443535-DNA,
pubmed-meshheading:11443535-Female,
pubmed-meshheading:11443535-Genotype,
pubmed-meshheading:11443535-Humans,
pubmed-meshheading:11443535-Linkage Disequilibrium,
pubmed-meshheading:11443535-Male,
pubmed-meshheading:11443535-Middle Aged,
pubmed-meshheading:11443535-Molecular Sequence Data,
pubmed-meshheading:11443535-Monte Carlo Method,
pubmed-meshheading:11443535-Panic Disorder,
pubmed-meshheading:11443535-Polymorphism, Genetic,
pubmed-meshheading:11443535-Reference Values,
pubmed-meshheading:11443535-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:11443535-Schizophrenia
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia.
|
| pubmed:affiliation |
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|