Source:http://linkedlifedata.com/resource/pubmed/id/11442452
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2001-7-9
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pubmed:abstractText |
Changes in the expression of heat shock protein 72 (HSP72) in response to atrophic-inducing perturbations of muscle involving chronic mechanical unloading and denervation were determined. Adult male Wistar rats were assigned randomly to a sedentary cage control (CON), hind limb unloading (HU, via tail suspension), HU plus tenotomy (HU + TEN), HU plus denervation (HU + DEN), or HU + TEN + DEN group. Tenotomy and DEN involved cutting the Achilles tendon and removing a segment of the sciatic nerve, respectively. After 5 days, HSP72 levels in the soleus of the HU + DEN and HU + TEN + DEN groups were 42 (P < 0.05) and 53% (P < 0.01) less than CON, respectively. Soleus weight decreased in both groups. Heat shock protein 72 levels in the plantaris of the HU + TEN, HU + DEN, and HU + TEN + DEN groups were 31, 25, and 30% lower than CON, respectively (P < 0.05). Plantaris weight decreased in the HU + DEN and HU + TEN + DEN, but not in the HU + TEN group. Hind limb unloading alone had little effect on the HSP72 level in either muscle. Reduced levels of HSP72 were associated with a decreased soleus (r=0.62, P < 0.01) and plantaris (r=0.78, P < 0.001) weight. These results indicate that the levels of HSP72 in both a slow and a fast rat plantarflexor are responsive to a chronic decrease in the levels of loading and/or activation and suggest that the neuromuscular activity level and the presence of innervation of a muscle are important factors that induce HSP72 expression.
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pubmed:keyword | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0001-6772
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11442452-Achilles Tendon,
pubmed-meshheading:11442452-Animals,
pubmed-meshheading:11442452-Atrophy,
pubmed-meshheading:11442452-Blotting, Western,
pubmed-meshheading:11442452-Body Weight,
pubmed-meshheading:11442452-Denervation,
pubmed-meshheading:11442452-HSP72 Heat-Shock Proteins,
pubmed-meshheading:11442452-Heat-Shock Proteins,
pubmed-meshheading:11442452-Hindlimb Suspension,
pubmed-meshheading:11442452-Male,
pubmed-meshheading:11442452-Muscle, Skeletal,
pubmed-meshheading:11442452-Organ Size,
pubmed-meshheading:11442452-Random Allocation,
pubmed-meshheading:11442452-Rats,
pubmed-meshheading:11442452-Rats, Wistar,
pubmed-meshheading:11442452-Sciatic Nerve,
pubmed-meshheading:11442452-Weight-Bearing
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of heat shock protein 72 in atrophied rat skeletal muscles.
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pubmed:affiliation |
Laboratory of Muscle Physiology, Faculty of Education, Kumamoto University, Japan. oishi@gpo.kumamoto-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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