Source:http://linkedlifedata.com/resource/pubmed/id/11441998
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-7-9
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pubmed:abstractText |
B lymphocytes that infiltrate the thyroid (Thy-B cells) in Graves' patients appear to be implicated in the pathophysiology of this disorder. The goal of the present study was to examine the nature of these Thy-B cells. To this end, Thy-B lymphocytes were isolated from surgical thyroidal samples, and their phenotype was determined by using mouse monoclonal antibodies (mAb) directed against a wide variety of surface markers, followed by flow cytometry multicolor analysis. The results show that most Thy-B cells (approximately 60%) exhibited IgM(+) IgD(low to -) surface immunoglobulin (Ig) profile, whereas the minor cell fraction (approximately 30%) consisted of switched IgG(+) memory B lymphocytes. Thy-B cells expressed low levels of CD5, CD23, and CD62L, which distinguished them from the resting B-cell pool, the major B-cell subset in the blood. In addition, they lacked CD38, CD10, and CD71, characteristic molecules for the germinal center B lymphocytes. In addition, Thy-B lymphocytes showed peculiar patterns both of adhesion molecules (CD62L(-), CD44(intermediate)), and of activation molecules (CD69(+), CD80(+), and, in part, CD95(+)). Taken together, these results suggest that the Thy-B lymphocyte subset consists of a combination of IgM(+) B cells resembling marginal zone B lymphocytes, and isotype-switched memory B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1050-7256
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
525-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11441998-Adolescent,
pubmed-meshheading:11441998-Adult,
pubmed-meshheading:11441998-Antigens, CD,
pubmed-meshheading:11441998-B-Lymphocyte Subsets,
pubmed-meshheading:11441998-B-Lymphocytes,
pubmed-meshheading:11441998-Biological Markers,
pubmed-meshheading:11441998-Cell Adhesion Molecules,
pubmed-meshheading:11441998-Female,
pubmed-meshheading:11441998-Flow Cytometry,
pubmed-meshheading:11441998-Graves Disease,
pubmed-meshheading:11441998-Humans,
pubmed-meshheading:11441998-Immunohistochemistry,
pubmed-meshheading:11441998-Immunologic Memory,
pubmed-meshheading:11441998-Phenotype,
pubmed-meshheading:11441998-Thyroid Gland
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pubmed:year |
2001
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pubmed:articleTitle |
Thyroid-infiltrating B lymphocytes in Graves' disease are related to marginal zone and memory B cell compartments.
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pubmed:affiliation |
Servicio de Inmunología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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