Linked Life Data

11441144

Source:http://linkedlifedata.com/resource/pubmed/id/11441144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-7-6
pubmed:abstractText
The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL(1), and HDL(2-3) cholesterol levels (P < 0.05) associated with increased LCAT activity (+57%) compared with control values. At 1 and 2 months of life, serum and lipoprotein cholesterol concentrations in macrosomic rats were similar to those of controls, whereas LCAT activity remained elevated about 1.5-fold. In addition, there was no change in hepatic cholesterol contents but hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and ACAT activities were higher in both macrosomic males and females than in their respective controls (P < 0.01). By 3 months, macrosomic rats had developed hypercholesterolemia with a rise in all lipoproteins. Enzyme activities were still increased in these mature macrosomic rats, and hepatic cholesteryl esters were higher only in macrosomic females. These data demonstrate an overproduction, combined with overutilization, of cholesterol during the phase of rapid growth in macrosomic rats. However, cholesterol oversynthesis exceeded its removal and was a major contributor to hypercholesterolemia in adult macrosomic rats. In conclusion, macrosomia was associated with alterations in cholesterol metabolism through adulthood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1152-9
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:11441144-Acetyl-CoA C-Acyltransferase, pubmed-meshheading:11441144-Animals, pubmed-meshheading:11441144-Cholesterol, pubmed-meshheading:11441144-Cholesterol 7-alpha-Hydroxylase, pubmed-meshheading:11441144-Diabetes Mellitus, Experimental, pubmed-meshheading:11441144-Female, pubmed-meshheading:11441144-Fetal Macrosomia, pubmed-meshheading:11441144-Growth, pubmed-meshheading:11441144-Hydroxymethylglutaryl CoA Reductases, pubmed-meshheading:11441144-Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent, pubmed-meshheading:11441144-Hyperglycemia, pubmed-meshheading:11441144-Lipoproteins, pubmed-meshheading:11441144-Liver, pubmed-meshheading:11441144-Phosphatidylcholine-Sterol O-Acyltransferase, pubmed-meshheading:11441144-Pregnancy, pubmed-meshheading:11441144-Pregnancy, Animal, pubmed-meshheading:11441144-Prenatal Exposure Delayed Effects, pubmed-meshheading:11441144-Rats, pubmed-meshheading:11441144-Rats, Wistar, pubmed-meshheading:11441144-Streptozocin
pubmed:year
2001
pubmed:articleTitle
Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.
pubmed:affiliation
Laboratoire de Physiologie Animale, Département de Biologie, Faculté des Sciences, Université de Tlemcen, Algeria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't