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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-7-6
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pubmed:abstractText |
Insulin-like growth factor-I (IGF-I) has been shown to protect against stroke in rats when administered intracerebroventricularly. However, this invasive method of administration is not practical for the large number of individuals who require treatment for stroke. Intranasal (IN) delivery offers a noninvasive method of bypassing the blood-brain barrier (BBB) to deliver IGF-I and other neurotrophic factors to the brain. Here, we demonstrate for the first time the therapeutic benefit of IN IGF-1 in rats following middle cerebral artery occlusion (MCAO).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11440750-Administration, Intranasal,
pubmed-meshheading:11440750-Animals,
pubmed-meshheading:11440750-Behavior, Animal,
pubmed-meshheading:11440750-Blood-Brain Barrier,
pubmed-meshheading:11440750-Body Weight,
pubmed-meshheading:11440750-Brain,
pubmed-meshheading:11440750-Brain Ischemia,
pubmed-meshheading:11440750-Dose-Response Relationship, Drug,
pubmed-meshheading:11440750-Infarction, Middle Cerebral Artery,
pubmed-meshheading:11440750-Insulin-Like Growth Factor I,
pubmed-meshheading:11440750-Male,
pubmed-meshheading:11440750-Movement Disorders,
pubmed-meshheading:11440750-Neurologic Examination,
pubmed-meshheading:11440750-Neuroprotective Agents,
pubmed-meshheading:11440750-Paresis,
pubmed-meshheading:11440750-Posture,
pubmed-meshheading:11440750-Rats,
pubmed-meshheading:11440750-Rats, Sprague-Dawley,
pubmed-meshheading:11440750-Recovery of Function,
pubmed-meshheading:11440750-Sensation Disorders
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pubmed:year |
2001
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pubmed:articleTitle |
Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage.
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pubmed:affiliation |
Stroke Lab, Alzheimer's Treatment and Research Center, Department of Neurology, Regions Hospital, 640 Jackson Street, Saint Paul, MN 55101-2595, USA. Liuxx159@tc.umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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