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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1975-9-24
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pubmed:abstractText |
The polyA-containing heterogenous nuclear RNA fraction separated from total rat liver nRNA by gel filtration on Sepharose 4B followed by affinity chromatography on polyU-Sepharose and containing predominantly the 45S components becomes enzymatically bound to homologous 80S ribosomes and polyribosomes at 0 degree C. If 80S ribosomes or polyribosomes with bound poly-a-containing HnRNA are subjected to a further incubation at 37 degree C, the original 45S RNA is gradually converted into smaller RNA species of 10- 35S which remain bound to the particle. This ribosome-dependent cleavage of larger HnRNA species into smaller RNA molecules may represent the ultimate step of mRNA maturation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4156155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4368966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4512402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4518107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4530986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4536742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4542191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4592421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4595729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4686199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4710584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4899460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-4949655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-5507919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1144064-5956959
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1144064-Adenine Nucleotides,
pubmed-meshheading:1144064-Animals,
pubmed-meshheading:1144064-Chromatography, Affinity,
pubmed-meshheading:1144064-Chromatography, Gel,
pubmed-meshheading:1144064-Liver,
pubmed-meshheading:1144064-Polynucleotides,
pubmed-meshheading:1144064-RNA,
pubmed-meshheading:1144064-RNA, Messenger,
pubmed-meshheading:1144064-Rats,
pubmed-meshheading:1144064-Ribosomes
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pubmed:year |
1975
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pubmed:articleTitle |
Ribosome-dependent conversion of polyA-containing heterogenous nuclear RNA into smaller RNA molecules.
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pubmed:publicationType |
Journal Article
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