Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2001-7-4
pubmed:abstractText
Smads serve as intracellular mediators of transforming growth factor beta (TGF-beta) signaling. After phosphorylation by activated type I TGF-beta receptors, Smad proteins translocate to the nucleus, where they serve as transcription factors and increase or decrease expression of TGF-beta target genes. Mice lacking one copy each of Smad2 and Smad3 suffered midgestation lethality due to liver hypoplasia and anemia, suggesting essential dosage requirements of TGF-beta signal components. This is likely due to abnormal adhesive properties of the mutant hepatocytes, which may result from a decrease in the level of the beta1-integrin and abnormal processing and localization of E-cadherin. Culture of mutant livers in vitro revealed the existence of a parallel developmental pathway mediated by hepatocyte growth factor (HGF), which could rescue the mutant phenotype independent of Smad activation. These pathways merge at the beta1-integrin, the level of which was increased by HGF in the cultured mutant livers. HGF treatment reversed the defects in cell proliferation and hepatic architecture in the Smad2(+/-); Smad3(+/-) livers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10064594, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10082515, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10198351, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10219856, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10373120, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10458166, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10559937, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10587642, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10708948, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-10775259, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-11016919, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-1436033, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-2211831, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-7493021, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-7544313, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-7854452, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-8600394, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-8682297, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-8774881, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-8940242, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9000597, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9020852, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9020907, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9199179, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9217007, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9427683, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9529255, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9620846, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9655392, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9689088, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9753318, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9755248, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9759503, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9779987, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9789329, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9794819, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9927192, http://linkedlifedata.com/resource/pubmed/commentcorrection/11438667-9930873
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5122-31
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:11438667-Animals, pubmed-meshheading:11438667-Mice, pubmed-meshheading:11438667-Liver, pubmed-meshheading:11438667-Mutation, pubmed-meshheading:11438667-Phosphorylation, pubmed-meshheading:11438667-Cell Division, pubmed-meshheading:11438667-Time Factors, pubmed-meshheading:11438667-Cells, Cultured, pubmed-meshheading:11438667-Heterozygote, pubmed-meshheading:11438667-Phenotype, pubmed-meshheading:11438667-Cell Adhesion, pubmed-meshheading:11438667-Immunohistochemistry, pubmed-meshheading:11438667-Mutagenesis, pubmed-meshheading:11438667-Signal Transduction, pubmed-meshheading:11438667-DNA-Binding Proteins, pubmed-meshheading:11438667-In Situ Hybridization, pubmed-meshheading:11438667-Hepatocyte Growth Factor, pubmed-meshheading:11438667-Cadherins, pubmed-meshheading:11438667-Active Transport, Cell Nucleus
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