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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-7-4
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pubmed:abstractText |
Nodal marginal zone B-cell lymphoma (NMZL) is actually considered as a distinct entity that must be distinguished from extra-nodal and splenic marginal zone lymphomas. To define the cell origin and the role of antigen stimulation we determined the nucleotide sequence of the tumor-related immunoglobulin heavy chain variable genes in 10 cases of NMZL. The results were also evaluated on the basis of the presence of chronic hepatitis C virus (HCV) infection. All 10 cases harbored VH somatic mutations with a sequence homology compared to the closest germline gene, ranging from 83.33 to 98.28%. Interestingly, different VH segments were preferentially used in HCV-positive and HCV-negative patients: three of five HCV-negative NMZLs used a VH4-34 segment joined with different D and JH segments whereas three of five HCV-positive NMZLs used a VH1-69 gene joined with a D3-22 and a JH4 segment, with very strong similarities in the CDR3s among the three different cases. These data indicate: 1) NMZL is derived from B cells that have experienced the germinal center reaction; 2) the preferential usage of a VH1-69 segment in the majority of the HCV-positive NMZL cases with similar CDR3s suggests the presence of a common antigen, probably a HCV antigen epitope, involved in the B-cell selection; and 3) the use of a VH4-34 segment suggests a role of yet unknown B-cell superantigen(s) in the selection of tumor B-cell precursors in HCV-negative NMZL.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10477699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10559454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10561313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10577857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10595937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-10845923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-11159532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-1382098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-1383822,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-3136072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-7579401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-7602095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-7717599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-7779254,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-8977195,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11438472-9894466
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11438472-Base Sequence,
pubmed-meshheading:11438472-Gene Rearrangement,
pubmed-meshheading:11438472-Hepacivirus,
pubmed-meshheading:11438472-Humans,
pubmed-meshheading:11438472-Immunoglobulin Heavy Chains,
pubmed-meshheading:11438472-Immunoglobulin Variable Region,
pubmed-meshheading:11438472-Immunoglobulins,
pubmed-meshheading:11438472-Lymphoma, B-Cell,
pubmed-meshheading:11438472-Molecular Sequence Data,
pubmed-meshheading:11438472-Mutation,
pubmed-meshheading:11438472-Polymerase Chain Reaction
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pubmed:year |
2001
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pubmed:articleTitle |
Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma.
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pubmed:affiliation |
Department of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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