Source:http://linkedlifedata.com/resource/pubmed/id/11437760
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2001-7-4
|
| pubmed:abstractText |
The reduction in acute pain perception following dextromethorphan has previously been investigated in patients undergoing general anaesthesia. This random and double-blind study examined the effects of pre-incisional oral dextromethorphan on postoperative pain and intravenous patient-controlled morphine demand in 60 day-surgery patients undergoing lower body surgery under lidocaine (1.6%-16 ml) epidural anaesthesia after receiving placebo, 60 or 90 mg dextromethorphan, 90 min pre-operatively. Postoperative pain was scored on a visual analogue scale from 1 to 10. In-hospital observation continued for 6 h and for 3 days at home; diclofenac was available throughout. Dextromethorphan-treated patients reported significantly (p < 0.05) less pain and sedation, and felt better. Patients who received dextromethorphan 90 mg had significantly (p < 0.05) lower heart and respiratory rates than those who received 60 mg. Medicated patients required half the morphine and diclofenac of placebo patients: 38% of patients who received 90 mg and 21% who received dextromethorphan 60 mg used no morphine or diclofenac whatsoever, a previously unreported finding.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Dextromethorphan,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0003-2409
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
616-22
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:11437760-Aged,
pubmed-meshheading:11437760-Ambulatory Surgical Procedures,
pubmed-meshheading:11437760-Analgesia, Epidural,
pubmed-meshheading:11437760-Analgesia, Patient-Controlled,
pubmed-meshheading:11437760-Analgesics, Opioid,
pubmed-meshheading:11437760-Anesthetics, Local,
pubmed-meshheading:11437760-Dextromethorphan,
pubmed-meshheading:11437760-Double-Blind Method,
pubmed-meshheading:11437760-Drug Administration Schedule,
pubmed-meshheading:11437760-Drug Therapy, Combination,
pubmed-meshheading:11437760-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11437760-Follow-Up Studies,
pubmed-meshheading:11437760-Heart Rate,
pubmed-meshheading:11437760-Humans,
pubmed-meshheading:11437760-Lidocaine,
pubmed-meshheading:11437760-Middle Aged,
pubmed-meshheading:11437760-Morphine,
pubmed-meshheading:11437760-Pain, Postoperative,
pubmed-meshheading:11437760-Respiration
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Combined pre-incisional oral dextromethorphan and epidural lidocaine for postoperative pain reduction and morphine sparing: a randomised double-blind study on day-surgery patients.
|
| pubmed:affiliation |
Department of Anaesthesiology and Critical Care Medicine, Post-Anaesthesia Care Unit, and Pain Clinic, Tel Aviv Sourasky Medical Centre, 6 Weizman Street, Tel Aviv 64239, Israel. graviw@tasmc.health.gov.il
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|