Source:http://linkedlifedata.com/resource/pubmed/id/11437506
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-7-4
|
| pubmed:abstractText |
The causative viruses of two diseases of rainbow trout, viral haemorrhagic septicaemia (VHS) and infectious pancreatic necrosis (IPN), exert much of their cytopathogenic effect in cell culture through the induction of apoptosis. In the present study, the TUNEL procedure was used to investigate the presence of apoptotic cells in different organs of rainbow trout infected with the viruses of VHS and IPN. VHS viral infection resulted in massive apoptosis in renal lymphoid tissue, where viral antigens were also detected. Large numbers of viral particles were observed in close proximity to apoptotic cells. Apoptosis was not detected in excretory cells of the renal tubules or in infected muscle cells. IPN virus did not induce apoptosis in the pancreas. However, the DNA degradation associated with apoptotic nuclei was observed in muscle lesions. Taken together, these results indicated that induction of apoptosis in vivo was critically influenced by the species of virus and the cell type. Moreover, it would seem likely that apoptosis contributed to the nature of the two diseases and to mortality.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0021-9975
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
124
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
300-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11437506-Animals,
pubmed-meshheading:11437506-Antigens, Viral,
pubmed-meshheading:11437506-Apoptosis,
pubmed-meshheading:11437506-Birnaviridae Infections,
pubmed-meshheading:11437506-DNA Fragmentation,
pubmed-meshheading:11437506-Fish Diseases,
pubmed-meshheading:11437506-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:11437506-In Situ Nick-End Labeling,
pubmed-meshheading:11437506-Infectious pancreatic necrosis virus,
pubmed-meshheading:11437506-Kidney Tubules,
pubmed-meshheading:11437506-Microscopy, Fluorescence,
pubmed-meshheading:11437506-Muscle, Skeletal,
pubmed-meshheading:11437506-Myocardium,
pubmed-meshheading:11437506-Oncorhynchus mykiss,
pubmed-meshheading:11437506-Pancreatic Diseases,
pubmed-meshheading:11437506-Rhabdoviridae,
pubmed-meshheading:11437506-Rhabdoviridae Infections,
pubmed-meshheading:11437506-Species Specificity
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Comparative study of in-situ cell death induced by the viruses of viral haemorrhagic septicaemia (VHS) and infectious pancreatic necrosis (IPN) in rainbow trout.
|
| pubmed:affiliation |
UnitAe de Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Jouy-en-Josas, 78352, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|