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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
2001-7-3
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pubmed:abstractText |
Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0171
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11435703-Animals,
pubmed-meshheading:11435703-Base Sequence,
pubmed-meshheading:11435703-Carrier Proteins,
pubmed-meshheading:11435703-Chromosomes, Human, Pair 4,
pubmed-meshheading:11435703-Contig Mapping,
pubmed-meshheading:11435703-Exons,
pubmed-meshheading:11435703-Expressed Sequence Tags,
pubmed-meshheading:11435703-Gene Expression Profiling,
pubmed-meshheading:11435703-Humans,
pubmed-meshheading:11435703-Internet,
pubmed-meshheading:11435703-Introns,
pubmed-meshheading:11435703-Lod Score,
pubmed-meshheading:11435703-Membrane Glycoproteins,
pubmed-meshheading:11435703-Mice,
pubmed-meshheading:11435703-Physical Chromosome Mapping,
pubmed-meshheading:11435703-RNA, Messenger,
pubmed-meshheading:11435703-Radiation Hybrid Mapping,
pubmed-meshheading:11435703-Sequence Homology
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pubmed:year |
2001
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pubmed:articleTitle |
The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.
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pubmed:affiliation |
Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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