11433361

Source:http://linkedlifedata.com/resource/pubmed/id/11433361

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015219, umls-concept:C1135894
pubmed:issue	7
pubmed:dateCreated	2001-7-2
pubmed:abstractText	One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100962779
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1471-0056
pubmed:author	pubmed-author:Eyre-WalkerAA, pubmed-author:HurstL DLD
pubmed:issnType	Print
pubmed:volume	2
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	549-55
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11433361-Chromosomes, Human, pubmed-meshheading:11433361-Dinucleotide Repeats, pubmed-meshheading:11433361-GC Rich Sequence, pubmed-meshheading:11433361-Genome, Human, pubmed-meshheading:11433361-Humans
pubmed:year	2001
pubmed:articleTitle	The evolution of isochores.
pubmed:affiliation	Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK. a.c.eyre-walker@sussex.ac.uk
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't