Source:http://linkedlifedata.com/resource/pubmed/id/11431713
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2001-6-29
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| pubmed:abstractText |
Whereas papillary renal cell carcinoma is now established as a subtype of renal cell neoplasia, division of these tumors into 2 distinctive morphotypes has been proposed. Type 1 tumors have cells with scanty pale cytoplasm arranged in a single layer on the basement membrane of papillary cores. In these tumors, psammoma bodies and foamy macrophages are frequently seen, and the tumors frequently express cytokeratin 7. Type 2 tumor cells have pseudostratified nuclei and usually have voluminous eosinophilic cytoplasm. Recent studies have supported this subclassification of papillary renal cell carcinoma by demonstrating differing genotypes for type 1 and 2 tumors. To further study the subclassification of papillary renal carcinoma, we compared clinical features, nuclear grade, stage, tumor growth kinetics, and survival in a series of 50 type 1 and 16 type 2 papillary renal cell carcinomas. Comparison of patient age at presentation, sex, and primary tumor size shows no significant difference between the 2 tumor types. Type 1 tumors were of significantly lower Fuhrman grade (P =.0001) and higher Robson stage (P =.009) than type 2 tumors. There was no significant difference when tumors were staged according to the TNM classification. Assessment of tumor growth kinetics showed significantly different mean silver-staining nucleolar organizer region (AgNOR) scores and Ki-67 indices (AgNOR type 1, 3.83, type 2, 7.24, P =.0001; Ki-67 type 1, 3.17%, type 2, 6.01%, P =.0002). Multivariate analysis showed tumor type (P =.03), presence of metastases (P =.04), AgNOR score (P =.001), and Ki-67 index (P =.03) to be independently associated with survival. These results provide evidence of the clinical utility of dividing papillary renal cell carcinomas into 2 types according to histologic characteristics.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0046-8177
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 by W.B. Saunders Company.
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| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
590-5
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11431713-Adult,
pubmed-meshheading:11431713-Aged,
pubmed-meshheading:11431713-Aged, 80 and over,
pubmed-meshheading:11431713-Carcinoma, Papillary,
pubmed-meshheading:11431713-Carcinoma, Renal Cell,
pubmed-meshheading:11431713-Cell Division,
pubmed-meshheading:11431713-Cell Nucleus,
pubmed-meshheading:11431713-Cytoplasm,
pubmed-meshheading:11431713-Female,
pubmed-meshheading:11431713-Humans,
pubmed-meshheading:11431713-Keratin-7,
pubmed-meshheading:11431713-Keratins,
pubmed-meshheading:11431713-Ki-67 Antigen,
pubmed-meshheading:11431713-Kidney Neoplasms,
pubmed-meshheading:11431713-Kinetics,
pubmed-meshheading:11431713-Macrophages,
pubmed-meshheading:11431713-Male,
pubmed-meshheading:11431713-Middle Aged,
pubmed-meshheading:11431713-Neoplasm Metastasis,
pubmed-meshheading:11431713-Neoplasm Staging,
pubmed-meshheading:11431713-Nucleolus Organizer Region,
pubmed-meshheading:11431713-Silver Staining,
pubmed-meshheading:11431713-Survival Rate
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| pubmed:year |
2001
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| pubmed:articleTitle |
Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases.
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| pubmed:affiliation |
Department of Pathology and Molecular Medicine, Wellington School of Medicine, University of Otago, Wellington, New Zealand.
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| pubmed:publicationType |
Journal Article,
Comparative Study
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