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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-6-29
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pubmed:abstractText |
Transcriptional downregulation of E-cadherin appears to be an important event in the progression of various epithelial tumors. SIP1 (ZEB-2) is a Smad-interacting, multi-zinc finger protein that shows specific DNA binding activity. Here, we report that expression of wild-type but not of mutated SIP1 downregulates mammalian E-cadherin transcription via binding to both conserved E2 boxes of the minimal E-cadherin promoter. SIP1 and Snail bind to partly overlapping promoter sequences and showed similar silencing effects. SIP1 can be induced by TGF-beta treatment and shows high expression in several E-cadherin-negative human carcinoma cell lines. Conditional expression of SIP1 in E-cadherin-positive MDCK cells abrogates E-cadherin-mediated intercellular adhesion and simultaneously induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ZEB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/snail family transcription factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1267-78
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pubmed:dateRevised |
2007-5-30
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pubmed:meshHeading |
pubmed-meshheading:11430829-Animals,
pubmed-meshheading:11430829-Cadherins,
pubmed-meshheading:11430829-Carcinoma,
pubmed-meshheading:11430829-Cell Adhesion,
pubmed-meshheading:11430829-Cell Line,
pubmed-meshheading:11430829-Cell Movement,
pubmed-meshheading:11430829-Cytoskeletal Proteins,
pubmed-meshheading:11430829-DNA-Binding Proteins,
pubmed-meshheading:11430829-Down-Regulation,
pubmed-meshheading:11430829-Epithelial Cells,
pubmed-meshheading:11430829-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11430829-Homeodomain Proteins,
pubmed-meshheading:11430829-Kidney,
pubmed-meshheading:11430829-Neoplasm Invasiveness,
pubmed-meshheading:11430829-RNA, Messenger,
pubmed-meshheading:11430829-Repressor Proteins,
pubmed-meshheading:11430829-Smad Proteins,
pubmed-meshheading:11430829-Trans-Activators,
pubmed-meshheading:11430829-Transcription, Genetic,
pubmed-meshheading:11430829-Transcription Factors,
pubmed-meshheading:11430829-Zinc Fingers,
pubmed-meshheading:11430829-beta Catenin
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pubmed:year |
2001
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pubmed:articleTitle |
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
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pubmed:affiliation |
Molecular Cell Biology Unit, Department of Molecular Biology, VIB-Ghent University, B-9000, Ghent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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