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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-29
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pubmed:abstractText |
A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-50
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11430013-Amino Acid Sequence,
pubmed-meshheading:11430013-Anti-HIV Agents,
pubmed-meshheading:11430013-Cells, Cultured,
pubmed-meshheading:11430013-Chromatography, High Pressure Liquid,
pubmed-meshheading:11430013-Cyclotides,
pubmed-meshheading:11430013-Cytopathogenic Effect, Viral,
pubmed-meshheading:11430013-Disulfides,
pubmed-meshheading:11430013-Humans,
pubmed-meshheading:11430013-Molecular Sequence Data,
pubmed-meshheading:11430013-Peptides, Cyclic,
pubmed-meshheading:11430013-Protein Conformation,
pubmed-meshheading:11430013-Rubiaceae,
pubmed-meshheading:11430013-Trees
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pubmed:year |
2001
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pubmed:articleTitle |
A novel anti-HIV macrocyclic peptide from Palicourea condensata.
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pubmed:affiliation |
Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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