Source:http://linkedlifedata.com/resource/pubmed/id/11429814
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2001-6-29
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pubmed:abstractText |
This paper describes conformational studies of proline-templated amino acids (PTAAs) based on the 3-azabicyclo[3.1.0]hexane system as well as conformational studies on short peptides composed of these PTAAs. NOE data, coupling constants, and molecular modeling are consistent with a flattened boat conformation for monomeric and oligomeric residues based on this bicyclic system. NMR studies on dimeric and trimeric oligomers are consistent with a populated poly-L-proline type II conformation in CDCl3 and D2O. Solution studies and molecular modeling predicts phi approximately -70 degrees, psi approximately 131 degrees, chi 1 approximately -57 degrees, and chi 2 approximately -158 degrees for oligomeric residues.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proline,
http://linkedlifedata.com/resource/pubmed/chemical/polyproline
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3263
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11429814-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:11429814-Dimerization,
pubmed-meshheading:11429814-Indicators and Reagents,
pubmed-meshheading:11429814-Molecular Conformation,
pubmed-meshheading:11429814-Molecular Structure,
pubmed-meshheading:11429814-Peptides,
pubmed-meshheading:11429814-Proline,
pubmed-meshheading:11429814-Protein Conformation,
pubmed-meshheading:11429814-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Poly-L-proline type II peptide mimics based on the 3-azabicyclo[3.1.0]hexane system.
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pubmed:affiliation |
Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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