Source:http://linkedlifedata.com/resource/pubmed/id/11429047
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-6-28
|
| pubmed:abstractText |
Modifying effects of scordinin, a biological active component in garlic, on diethylnitrosamine (DEN)- and phenobarbital (PB)-induced hepatocarcinogenesis were examined in rats. Male F344 rats, 5 weeks old, were divided into 8 groups. After a week, groups 1 - 5 were given DEN (100 mg / kg body weight, i.p.) once a week for 3 weeks, whereas groups 6 - 8 received vehicle treatment. Group 2 was given 600 ppm scordinin-containing diet in the initiation phase. From 4 weeks after the start of experiment, groups 3 and 5 were fed scordinin, and groups 1 - 3 and 7 received drinking water containing 500 ppm PB. Group 6 was given scordinin diet alone throughout the experiment (24 weeks). The incidences of hepatocellular adenoma and carcinoma were significantly smaller in group 3 than those in group 1 (P < 0.005 and P < 0.05, respectively). The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0.01 and P < 0.0001, respectively). Glutathione S-transferase placental form-positive foci were also significantly decreased by scordinin treatment in the initiation or promotion phase. Scordinin significantly decreased the mean number of nucleolar organizer regions' protein (AgNORs) / nucleus in hepatocellular adenoma and carcinoma. AgNORs / nucleus in the non-lesional area was also significantly decreased by scordinin treatment during the promotion phase. These results suggest that scordinin is a promising chemopreventive agent for liver neoplasia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/scordinin
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0910-5050
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
92
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11429047-Adenoma, Liver Cell,
pubmed-meshheading:11429047-Animals,
pubmed-meshheading:11429047-Anticarcinogenic Agents,
pubmed-meshheading:11429047-Body Weight,
pubmed-meshheading:11429047-Carcinogens,
pubmed-meshheading:11429047-Carcinoma, Hepatocellular,
pubmed-meshheading:11429047-Cell Division,
pubmed-meshheading:11429047-Cell Nucleus,
pubmed-meshheading:11429047-Diethylnitrosamine,
pubmed-meshheading:11429047-Dose-Response Relationship, Drug,
pubmed-meshheading:11429047-Glutathione Transferase,
pubmed-meshheading:11429047-Liver,
pubmed-meshheading:11429047-Liver Neoplasms,
pubmed-meshheading:11429047-Male,
pubmed-meshheading:11429047-Models, Chemical,
pubmed-meshheading:11429047-Neoplasms,
pubmed-meshheading:11429047-Nucleolus Organizer Region,
pubmed-meshheading:11429047-Organ Size,
pubmed-meshheading:11429047-Phenobarbital,
pubmed-meshheading:11429047-Plant Extracts,
pubmed-meshheading:11429047-Rats,
pubmed-meshheading:11429047-Rats, Inbred F344,
pubmed-meshheading:11429047-Time Factors
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| pubmed:year |
2001
|
| pubmed:articleTitle |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
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| pubmed:affiliation |
Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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