Source:http://linkedlifedata.com/resource/pubmed/id/11429023
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2001-6-28
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| pubmed:abstractText |
Toxoplasmosis is a rare but life-threatening complication of allogeneic stem-cell transplantation. Polymerase chain reaction (PCR) offers the possibility to make the diagnosis earlier than conventional techniques, and is then expected to improve the prognosis. We undertook a prospective screening using a competitive PCR in blood in 32 stem-cell transplant recipients. The sampling covered the first 150 days post-transplant, at days 21, 30, 45, 60, 90, 120, and 150. Twenty-four patients had anti-toxoplasma antibodies before transplant. Three of them (12.5%) had transient PCR-positive samples at 21, 45, and 90 days post-transplant, respectively. The three PCR-positive patients were febrile but had no funduscopic examination or cerebral computerised tomography (CT) scan abnormalities. The PCR signal disappeared when the patients were given trimethoprim-sulfamethoxazole, and no full-blown toxoplasmosis was observed. Toxoplasma reactivation evidenced using PCR is frequent in seropositive patients not receiving trimethoprim-sulfamethoxazole during the 1-3 months post-transplant. Toxoplasma PCR should be included in the diagnostic strategy of fever of unexplained origin in allogeneic stem-cell transplant recipients. Then, prompt specific therapy can be initiated to avoid development of full-blown toxoplasmosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1398-2273
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
127-32
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11429023-Adult,
pubmed-meshheading:11429023-Anemia, Aplastic,
pubmed-meshheading:11429023-Animals,
pubmed-meshheading:11429023-Anti-Infective Agents,
pubmed-meshheading:11429023-Antibodies, Protozoan,
pubmed-meshheading:11429023-Child,
pubmed-meshheading:11429023-Female,
pubmed-meshheading:11429023-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11429023-Humans,
pubmed-meshheading:11429023-Leukemia,
pubmed-meshheading:11429023-Male,
pubmed-meshheading:11429023-Middle Aged,
pubmed-meshheading:11429023-Polymerase Chain Reaction,
pubmed-meshheading:11429023-Prospective Studies,
pubmed-meshheading:11429023-Toxoplasma,
pubmed-meshheading:11429023-Toxoplasmosis,
pubmed-meshheading:11429023-Transplantation, Homologous,
pubmed-meshheading:11429023-Trimethoprim-Sulfamethoxazole Combination
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Prospective study of toxoplasma reactivation by polymerase chain reaction in allogeneic stem-cell transplant recipients.
|
| pubmed:affiliation |
Laboratoire de Parasitologie-Mycologie, Hôpital Henri Mondor, Créteil, France. bretagne@univ-paris12.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|