Source:http://linkedlifedata.com/resource/pubmed/id/11428874
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-6-28
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| pubmed:abstractText |
To test the hypothesis that extended antibiotic prophylaxis increases the risk of Clostridium difficile -associated diarrhoea (CDAD), we conducted a retrospective cohort study of 2641 patients under-going cardiovascular surgery. Main outcome measures were the duration of prophylaxis (< 48 h vs. > 48 h) and the occurrence of CDAD. CDAD occurred in 31 patients (1.2%), who were significantly older (70 +/- 9 y vs. 66 +/- 10 y; P = 0.03), received more therapeutic antibiotics (2.2 +/- 1.9 vs. 0.4 +/- 0.9; P = 0.001) and had a longer postoperative hospital stay (26 +/- 19 d vs. 9 +/- 8 d; P < 0.001) than non-cases. After adjusting for confounding, we did not observe an association between prolonged prophylaxis and CDAD [adjusted odds ratio (AOR), 0.8; CI, 0.4-1.8]. In contrast, three independent predictors were identified: increasing length of hospital stay (AOR per one-day-increment, 1.03; CI, 1.01-1.05), and treatment with third generation cephalosporins (AOR, 5.9; CI, 2.2-16.0) or beta-lactam-beta-lactamase inhibitor combinations (AOR, 4.6; CI, 1.7-12.3). Our results did not confirm that extended prophylaxis after clean surgery increases the risk of CDAD, which remains an uncommon postoperative complication, associated even with short antibiotic exposure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0195-6701
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 The Hospital Infection Society.
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| pubmed:issnType |
Print
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| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
93-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11428874-Age Distribution,
pubmed-meshheading:11428874-Aged,
pubmed-meshheading:11428874-Antibiotic Prophylaxis,
pubmed-meshheading:11428874-Boston,
pubmed-meshheading:11428874-Cardiovascular Surgical Procedures,
pubmed-meshheading:11428874-Clostridium Infections,
pubmed-meshheading:11428874-Diarrhea,
pubmed-meshheading:11428874-Enterocolitis, Pseudomembranous,
pubmed-meshheading:11428874-Female,
pubmed-meshheading:11428874-Humans,
pubmed-meshheading:11428874-Male,
pubmed-meshheading:11428874-Middle Aged,
pubmed-meshheading:11428874-Multivariate Analysis,
pubmed-meshheading:11428874-Odds Ratio,
pubmed-meshheading:11428874-Postoperative Care,
pubmed-meshheading:11428874-Retrospective Studies,
pubmed-meshheading:11428874-Risk,
pubmed-meshheading:11428874-Time Factors
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| pubmed:year |
2001
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| pubmed:articleTitle |
Antibiotic prophylaxis and the risk of Clostridium difficile-associated diarrhoea.
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| pubmed:affiliation |
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. harbarth@post.harvard.edu
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| pubmed:publicationType |
Journal Article
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