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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-6-28
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|
pubmed:abstractText |
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta-induced neurotoxicity and some recent advances in the development of A beta-related therapeutic strategies.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
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|
pubmed:issn |
1075-2617
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
7
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|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-49
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11428545-Alzheimer Disease,
pubmed-meshheading:11428545-Amino Acid Sequence,
pubmed-meshheading:11428545-Amyloid beta-Peptides,
pubmed-meshheading:11428545-Animals,
pubmed-meshheading:11428545-Circular Dichroism,
pubmed-meshheading:11428545-Humans,
pubmed-meshheading:11428545-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11428545-Models, Biological,
pubmed-meshheading:11428545-Models, Chemical,
pubmed-meshheading:11428545-Molecular Sequence Data,
pubmed-meshheading:11428545-Peptides,
pubmed-meshheading:11428545-Protein Binding,
pubmed-meshheading:11428545-Protein Isoforms,
pubmed-meshheading:11428545-Protein Structure, Secondary,
pubmed-meshheading:11428545-Protein Structure, Tertiary
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
The amyloid-beta peptide and its role in Alzheimer's disease.
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pubmed:affiliation |
School of Chemistry, The University of Melbourne, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
