Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-6-27
pubmed:abstractText
O-antigen-specific monoclonal antibodies (MAbs) are currently being generated to develop an O-serotyping scheme for the genus Acinetobacter and to provide potent tools to study the diversity of O-antigens among Acinetobacter strains. In this report, Acinetobacter baumannii strains from the Czech Republic and from two clonal groups identified in Northwestern Europe (termed clones I and II) were investigated for their reactivity with a panel of O-antigen-specific MAbs generated against Acinetobacter strains from various species. The bacteria were characterized for their ribotype, biotype, and antibiotic susceptibility and the presence of the 8.7-kb plasmid pAN1. By using the combination of these typing profiles, the Czech strains could be classified into four previously defined groups (A. Nemec, L. Janda, O. Melter, and L. Dijkshoorn, J. Med. Microbiol. 48:287-296, 1999): two relatively homogeneous groups of multiresistant strains (termed groups A and B), a heterogeneous group of other multiresistant strains, and a group of susceptible strains. O-antigen reactivity was observed primarily with MAbs generated against Acinetobacter calcoaceticus and Acinetobacter baumannii strains. A comparison of reaction patterns confirmed the previously hypothesized clonal relationship between group A and clone I strains, which are also similar in other properties. The results show that there is limited O-antigen variability among strains with similar geno- and phenotypic characteristics and are suggestive of a high prevalence of certain A. baumannii serotypes in the clinical environment. It is also shown that O-antigen-specific MAbs are useful for the follow-up of strains causing outbreaks in hospitals.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-10225830, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-10325309, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-10334596, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-10406970, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-1375194, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-2751895, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-2799067, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-846390, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-8735109, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-9303951, http://linkedlifedata.com/resource/pubmed/commentcorrection/11427571-9574685
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2576-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
O-antigen diversity among Acinetobacter baumannii strains from the Czech Republic and Northwestern Europe, as determined by lipopolysaccharide-specific monoclonal antibodies.
pubmed:affiliation
Division of Medical and Biochemical Microbiology, Research Center Borstel, Borstel, Germany. rpanto@scripps.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't