Source:http://linkedlifedata.com/resource/pubmed/id/11427228
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-6-27
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pubmed:abstractText |
Plaques from the coronary arteries of explanted hearts showed massive calcification (15-fold increase) with a loss of scleroproteins (-36%), an increase in the collagen to elastin ratio (twofold) and activation (+15%) of matrix metalloproteinase-2 (MMP-2). Plaque-free portions of the coronary artery gave results similar to those obtained with the internal mammary artery. There was a significant correlation between plaque calcification and MMP-2 activation, suggesting that the two processes may be linked.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11427228-Adult,
pubmed-meshheading:11427228-Aged,
pubmed-meshheading:11427228-Calcinosis,
pubmed-meshheading:11427228-Coronary Disease,
pubmed-meshheading:11427228-Coronary Vessels,
pubmed-meshheading:11427228-Enzyme Activation,
pubmed-meshheading:11427228-Extracellular Matrix,
pubmed-meshheading:11427228-Humans,
pubmed-meshheading:11427228-Matrix Metalloproteinase 2,
pubmed-meshheading:11427228-Middle Aged,
pubmed-meshheading:11427228-Scleroproteins
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pubmed:year |
2001
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pubmed:articleTitle |
Activation of metalloproteinase-2, loss of matrix scleroprotein content and coronary artery calcification.
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pubmed:affiliation |
Laboratoire de Pharmacologie, EA 3116, UHP-Nancy, 5 rue Albert Lebrun, 54000 Nancy, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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