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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-6-26
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pubmed:abstractText |
To examine the effects of calcium antagonists nimodipine and magnesium sulfate (MgSO4) on tissue endogenous antioxidant levels, the authors studied superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rabbit brain 1 hour after experimental head trauma. Forty New Zealand rabbits were anesthetized and randomly divided into four groups. Group 1 (n = 10) was the sham operated group. Group 2 (n = 10), the control group, received head trauma and no treatment. Group 3 (n = 10) received head trauma and intravenous (IV) 2 microgr/kg nimodipine. Group 4 (n = 10) received head trauma and IV 100 mg/kg MgSO4. Head trauma was delivered by performing a craniectomy over the right hemisphere and dropping a weight of 20 g from a height of 40 cm. In the right (traumatized) hemisphere, SOD and GPx decreased by 57.60% +/- 9.60% and 72.93% +/- 5.51% respectively from sham values. Magnesium sulfate, but not nimodipine, reduced the magnitude of decrease of SOD and GPx to 19.43% +/- 7.15% and 39.01% +/- 7.92% respectively from sham values. In the left (nontraumatized) hemisphere, MgSO4 increased SOD to 42.43% +/- 24.76% above sham values. The authors conclude that MgSO4 treatment inhibited the decrease in SOD and GPx levels in experimental brain injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0898-4921
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11426097-Analysis of Variance,
pubmed-meshheading:11426097-Animals,
pubmed-meshheading:11426097-Antioxidants,
pubmed-meshheading:11426097-Blood Pressure,
pubmed-meshheading:11426097-Brain,
pubmed-meshheading:11426097-Brain Injuries,
pubmed-meshheading:11426097-Carbon Dioxide,
pubmed-meshheading:11426097-Cerebral Cortex,
pubmed-meshheading:11426097-Craniocerebral Trauma,
pubmed-meshheading:11426097-Craniotomy,
pubmed-meshheading:11426097-Female,
pubmed-meshheading:11426097-Functional Laterality,
pubmed-meshheading:11426097-Glutathione Peroxidase,
pubmed-meshheading:11426097-Heart Rate,
pubmed-meshheading:11426097-Ketamine,
pubmed-meshheading:11426097-Magnesium Sulfate,
pubmed-meshheading:11426097-Male,
pubmed-meshheading:11426097-Nimodipine,
pubmed-meshheading:11426097-Oxygen,
pubmed-meshheading:11426097-Partial Pressure,
pubmed-meshheading:11426097-Rabbits,
pubmed-meshheading:11426097-Superoxide Dismutase,
pubmed-meshheading:11426097-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Effects of nimodipine and magnesium sulfate on endogenous antioxidant levels in brain tissue after experimental head trauma.
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pubmed:affiliation |
Department of Neurosurgery, Selçuk University, Faculty of Medicine, Konya, Turkey.
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pubmed:publicationType |
Journal Article,
Comparative Study
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