Linked Life Data

11424994

Source:http://linkedlifedata.com/resource/pubmed/id/11424994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-6-26
pubmed:abstractText
Genetic influences on psychiatric disorders are well established. However, localization of the genes responsible for these effects has proved extremely difficult. One emerging strategy that may circumvent some of these difficulties is the use of quantitative risk factors, or endophenotypes, which are correlated with disease and may be closer to underlying genetic liability and to gene action than are diagnostic phenotypes. Genetic studies of quantitative endophenotypes require different sampling and analysis strategies than studies of disease state. The rationale for using quantitative risk factors as indicators of disease liability and the optimal study design for localizing genes influencing such risk factors are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0148-7299
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design.
pubmed:affiliation
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.