Itraconazole is a potent inhibitor of CYP3A4 activity and is often used in combination with corticosteroids. Since the latter are partly metabolized by CYP3A4, we studied the interaction between itraconazole, prednisone and methylprednisolone in healthy male subjects.
Departments of Pharmacology and Internal Medicine, Assistance-Publique Hôpitaux de Paris, Pitié-Salpêtrière, Paris andJanssen Laboratories, Val de Reuil, France.
