Linked Life Data

11421580

Source:http://linkedlifedata.com/resource/pubmed/id/11421580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-6-25
pubmed:abstractText
Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this context, the main objective of the present study was to better understand the contributions of LRP and LDL-R to the in vivo neurotrophic effects of apoE. For this purpose, apoE-deficient and receptor-associated protein (RAP)-deficient mice were infused with recombinant apoE3, RAP, or saline. Infusion of apoE3 into apoE-deficient mice resulted in amelioration of degenerative alterations of pyramidal neurons, but had no effect on somatostatin-producing interneurons. In contrast, infusion of apoE3 into RAP-deficient mice resulted in amelioration of degenerative alterations of somatostatin-producing interneurons. LRP and LDL-R levels were significantly reduced in RAP-deficient mice, but significantly increased in the apoE-deficient mice. In contrast, levels of apoE were reduced in the RAP-deficient mice compared to wildtype controls, suggesting that neurotrophic effects of apoE3 in the RAP-deficient mice were related to a combined deficit in endogenous apoE and selected apoE receptors. Furthermore, in apoE-deficient mice, infusion of apoE3 had a neurotrophic effect on somatostatin-producing interneurons only when combined with RAP, suggesting that increased expression of apoE receptors in apoE-deficient mice prevented apoE from rescuing somatostatin-producing neurons. This study supports the contention that some of the in vivo neurotrophic effects of apoE are mediated by LRP and LDL-R and that a critical balance between levels of apoE and its receptors is necessary for the differential neurotrophic effects to appear.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-4886
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Academic Press.
pubmed:issnType
Print
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-26
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11421580-Animals, pubmed-meshheading:11421580-Apolipoprotein E3, pubmed-meshheading:11421580-Apolipoproteins E, pubmed-meshheading:11421580-Heymann Nephritis Antigenic Complex, pubmed-meshheading:11421580-Hippocampus, pubmed-meshheading:11421580-Injections, Intraventricular, pubmed-meshheading:11421580-Interneurons, pubmed-meshheading:11421580-Low Density Lipoprotein Receptor-Related Protein-1, pubmed-meshheading:11421580-Membrane Glycoproteins, pubmed-meshheading:11421580-Mice, pubmed-meshheading:11421580-Mice, Inbred C57BL, pubmed-meshheading:11421580-Mice, Knockout, pubmed-meshheading:11421580-Microtubule-Associated Proteins, pubmed-meshheading:11421580-Neocortex, pubmed-meshheading:11421580-Nerve Growth Factors, pubmed-meshheading:11421580-Neurons, pubmed-meshheading:11421580-Pyramidal Cells, pubmed-meshheading:11421580-Receptors, Lipoprotein, pubmed-meshheading:11421580-Recombinant Proteins, pubmed-meshheading:11421580-Somatostatin
pubmed:year
2001
pubmed:articleTitle
Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.
pubmed:affiliation
Department of Neurosciences, University of California-San Diego, La Jolla, CA 92093-0624, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't