| pubmed-article:11420121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0085424 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0052088 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11420121 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:11420121 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11420121 | pubmed:dateCreated | 2001-6-22 | lld:pubmed |
| pubmed-article:11420121 | pubmed:abstractText | The amiloride-inhibitable Na(+)/H(+) antiporter plays an important role in macrophage activation. The intracellular pathways leading to interleukin (IL)-12 p40 production by activated macrophages are incompletely understood. In the present study, we examined the contribution of the Na(+)/H(+) antiporter to the production of IL-12 p40. Amiloride or its analogs decreased the production of IL-12 p40 in macrophages stimulated with bacterial lipopolysaccharide and interferon-gamma. The order of potency of amiloride analogs was consistent with the proposition that the effect of amiloride is mediated by the inhibition of the Na(+)/H(+) antiporter. The effect of amiloride was post-transcriptional, as IL-12 p40 mRNA levels induced by lipopolysaccharide and interferon-gamma were not affected by this inhibitor. Furthermore, the inhibitory effect of amiloride on IL-12 p40 production was not a result of interference with the activation of the p38 and p42/44 mitogen-activated protein kinases or c-Jun kinase. In summary, the production of IL-12 p40 requires a functional Na(+)/H(+) antiporter. | lld:pubmed |
| pubmed-article:11420121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11420121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11420121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11420121 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11420121 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:11420121 | pubmed:author | pubmed-author:DeitchE AEA | lld:pubmed |
| pubmed-article:11420121 | pubmed:author | pubmed-author:SzabóCC | lld:pubmed |
| pubmed-article:11420121 | pubmed:author | pubmed-author:MableyJ GJG | lld:pubmed |
| pubmed-article:11420121 | pubmed:author | pubmed-author:HaskóGG | lld:pubmed |
| pubmed-article:11420121 | pubmed:author | pubmed-author:NémethZ HZH | lld:pubmed |
| pubmed-article:11420121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11420121 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11420121 | pubmed:volume | 1539 | lld:pubmed |
| pubmed-article:11420121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11420121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11420121 | pubmed:pagination | 233-42 | lld:pubmed |
| pubmed-article:11420121 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11420121 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11420121 | pubmed:articleTitle | Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages. | lld:pubmed |
| pubmed-article:11420121 | pubmed:affiliation | Department of Surgery, UMD-New Jersey Medical School, Newark, NJ 07103, USA. | lld:pubmed |
| pubmed-article:11420121 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11420121 | lld:pubmed |
