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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-6-22
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pubmed:abstractText |
-Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) are 2 types of intermediate filament protein. Expression of CK7 is seen in the majority of primary urinary bladder carcinomas. CK20 is restricted to superficial and occasional intermediate cells of the normal urothelium of the bladder. Aberrant CK20 expression has been documented in urothelial carcinoma and has proved useful as an ancillary diagnostic aid for urinary bladder tumor. Our hypothesis is that the pattern of CK7 and CK20 expression in metastatic urothelial carcinoma duplicates the expression of the same markers in the primary tumors. Therefore, immunohistochemical staining of metastatic tumors for these 2 markers may be helpful for differential diagnosis in ambiguous metastatic tumor deposits.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-9985
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
921-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11419977-Adult,
pubmed-meshheading:11419977-Aged,
pubmed-meshheading:11419977-Aged, 80 and over,
pubmed-meshheading:11419977-Carcinoma,
pubmed-meshheading:11419977-Female,
pubmed-meshheading:11419977-Humans,
pubmed-meshheading:11419977-Immunohistochemistry,
pubmed-meshheading:11419977-Intermediate Filament Proteins,
pubmed-meshheading:11419977-Keratin-20,
pubmed-meshheading:11419977-Keratin-7,
pubmed-meshheading:11419977-Keratins,
pubmed-meshheading:11419977-Lymph Nodes,
pubmed-meshheading:11419977-Lymphatic Metastasis,
pubmed-meshheading:11419977-Male,
pubmed-meshheading:11419977-Middle Aged,
pubmed-meshheading:11419977-Staining and Labeling,
pubmed-meshheading:11419977-Tissue Distribution,
pubmed-meshheading:11419977-Urinary Bladder Neoplasms
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pubmed:year |
2001
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pubmed:articleTitle |
Cytokeratin 7 and cytokeratin 20 in primary urinary bladder carcinoma and matched lymph node metastasis.
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pubmed:affiliation |
Department of Pathology, Indiana University School of Medicine, Indianapolis, Ind. 46202, USA.
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pubmed:publicationType |
Journal Article
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