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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-6-21
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pubmed:abstractText |
The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL17 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl17 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL17,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alphaXbeta2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/thymic stromal lymphopoietin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BazanJ FJF,
pubmed-author:CliffordTT,
pubmed-author:GormanD MDM,
pubmed-author:JohnstonJJ,
pubmed-author:KasteleinR ARA,
pubmed-author:Liu Mr,
pubmed-author:LiuY JYJ,
pubmed-author:RecheP APA,
pubmed-author:SoumelisVV,
pubmed-author:SpitsHH,
pubmed-author:TravisMM,
pubmed-author:ZurawskiS MSM,
pubmed-author:de Waal MalefytRR
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11418668-Amino Acid Sequence,
pubmed-meshheading:11418668-Animals,
pubmed-meshheading:11418668-Cell Line,
pubmed-meshheading:11418668-Cell Separation,
pubmed-meshheading:11418668-Cells, Cultured,
pubmed-meshheading:11418668-Chemokine CCL17,
pubmed-meshheading:11418668-Chemokines, CC,
pubmed-meshheading:11418668-Computational Biology,
pubmed-meshheading:11418668-Cytokines,
pubmed-meshheading:11418668-Dendritic Cells,
pubmed-meshheading:11418668-Humans,
pubmed-meshheading:11418668-Integrin alphaXbeta2,
pubmed-meshheading:11418668-Interleukin-7,
pubmed-meshheading:11418668-Macromolecular Substances,
pubmed-meshheading:11418668-Mice,
pubmed-meshheading:11418668-Molecular Sequence Data,
pubmed-meshheading:11418668-Monocytes,
pubmed-meshheading:11418668-Myeloid Cells,
pubmed-meshheading:11418668-Receptors, Cytokine,
pubmed-meshheading:11418668-Receptors, Interleukin-7,
pubmed-meshheading:11418668-Stromal Cells,
pubmed-meshheading:11418668-Thymus Gland
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pubmed:year |
2001
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pubmed:articleTitle |
Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.
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pubmed:affiliation |
DNAX Research Institute, Palo Alto, CA 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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