Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-6-21
pubmed:abstractText
The molecular mechanisms that contribute to autoimmunity remain poorly defined. While inflammation is considered to be one of the major checkpoints in autoimmune disease progression, very little is known about the initiating events that trigger inflammation. We have studied transgenic mice expressing the prosurvival molecule protein kinase B/Akt under control of a T cell-specific CD2 promoter. In this study, we demonstrate that aged mice develop lymphadenopathy and splenomegaly that result from an accumulation of CD4, CD8, and unexpectedly B cells. An increased proportion of T cells express activation markers, while T cell proliferative responses remain normal. B cells are hyperproliferative in response to anti-IgM F(ab')(2) and anti-CD40, and increased IgA and IgG2a were found in the sera. In addition, a profound multiorgan lymphocytic infiltration is observed, and T cells from these mice display a defect in Fas-mediated apoptosis, which may be the mechanism underlying this phenotype. Therefore, T cell expression of active protein kinase B can alter T cell homeostasis, indirectly influence B cell homeostasis, and promote inflammation in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11418630-Animals, pubmed-meshheading:11418630-Antigens, CD95, pubmed-meshheading:11418630-Autoimmune Diseases, pubmed-meshheading:11418630-B-Lymphocytes, pubmed-meshheading:11418630-Cell Death, pubmed-meshheading:11418630-Enzyme Activation, pubmed-meshheading:11418630-Fas Ligand Protein, pubmed-meshheading:11418630-Homeostasis, pubmed-meshheading:11418630-Humans, pubmed-meshheading:11418630-Hyperplasia, pubmed-meshheading:11418630-Inflammation, pubmed-meshheading:11418630-Lymph Nodes, pubmed-meshheading:11418630-Lymphocyte Activation, pubmed-meshheading:11418630-Lymphoproliferative Disorders, pubmed-meshheading:11418630-Membrane Glycoproteins, pubmed-meshheading:11418630-Mice, pubmed-meshheading:11418630-Mice, Inbred C57BL, pubmed-meshheading:11418630-Mice, Inbred DBA, pubmed-meshheading:11418630-Mice, Transgenic, pubmed-meshheading:11418630-Peyer's Patches, pubmed-meshheading:11418630-Protein-Serine-Threonine Kinases, pubmed-meshheading:11418630-Proto-Oncogene Proteins, pubmed-meshheading:11418630-Proto-Oncogene Proteins c-akt, pubmed-meshheading:11418630-T-Lymphocytes
pubmed:year
2001
pubmed:articleTitle
Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation.
pubmed:affiliation
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't