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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-6-21
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pubmed:abstractText |
Immunization of mice containing mutations that inactivate the TCR Cbeta and Cdelta genes with the T cell-independent (TI) type 2 Ag (4-hydroxy-3-nitrophenyl)acetyl-Ficoll induces clusters of peanut agglutinin-binding B cells in the spleen. These clusters are histologically indistinguishable from germinal centers (GCs) typical of T cell-dependent immune responses. They are located in follicles, and contain mature follicular dendritic cells, immune complex deposits, and B cells that display the phenotypic qualities of conventional GC B cells. However, the kinetics of this TI GC response differ from T cell-dependent GC responses in being rapidly induced and of short duration. Moreover, the Ab V genes expressed in TI GCs have not undergone somatic hypermutation. Therefore, T cells may be required for B cell differentiation processes associated with the intermediate and latter stages of the GC reaction, but they are dispensable for the induction and initial development of this response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-20
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11418626-Animals,
pubmed-meshheading:11418626-Antigens, T-Independent,
pubmed-meshheading:11418626-B-Lymphocytes,
pubmed-meshheading:11418626-Base Sequence,
pubmed-meshheading:11418626-Cell Aggregation,
pubmed-meshheading:11418626-Cell Differentiation,
pubmed-meshheading:11418626-Gene Expression Regulation,
pubmed-meshheading:11418626-Germinal Center,
pubmed-meshheading:11418626-Immunoglobulin Heavy Chains,
pubmed-meshheading:11418626-Immunoglobulin Variable Region,
pubmed-meshheading:11418626-Immunophenotyping,
pubmed-meshheading:11418626-Lymphopenia,
pubmed-meshheading:11418626-Mice,
pubmed-meshheading:11418626-Mice, Inbred C57BL,
pubmed-meshheading:11418626-Mice, Knockout,
pubmed-meshheading:11418626-Molecular Sequence Data,
pubmed-meshheading:11418626-Mutation,
pubmed-meshheading:11418626-Peanut Agglutinin,
pubmed-meshheading:11418626-Spleen,
pubmed-meshheading:11418626-T-Lymphocytes
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pubmed:year |
2001
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pubmed:articleTitle |
Cutting edge: germinal centers can be induced in the absence of T cells.
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pubmed:affiliation |
Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, PA 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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