Source:http://linkedlifedata.com/resource/pubmed/id/11418486
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-6-21
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pubmed:abstractText |
Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1-deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1-deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1-dependent manner. These results suggest FasL-mediated caspase-1-dependent IL-18 secretion in aGVHD in mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11418486-Acute Disease,
pubmed-meshheading:11418486-Animals,
pubmed-meshheading:11418486-Caspase 1,
pubmed-meshheading:11418486-Disease Models, Animal,
pubmed-meshheading:11418486-Fas Ligand Protein,
pubmed-meshheading:11418486-Female,
pubmed-meshheading:11418486-Graft vs Host Disease,
pubmed-meshheading:11418486-Interleukin-18,
pubmed-meshheading:11418486-Membrane Glycoproteins,
pubmed-meshheading:11418486-Mice,
pubmed-meshheading:11418486-Mice, Mutant Strains,
pubmed-meshheading:11418486-Tissue Transplantation
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pubmed:year |
2001
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pubmed:articleTitle |
Fas ligand-induced caspase-1-dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease.
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pubmed:affiliation |
Second Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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