Linked Life Data

1141671

Source:http://linkedlifedata.com/resource/pubmed/id/1141671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-9-13
pubmed:abstractText
The dorsal column nuclei of young, old, and vitamin E-supplemented old mice were examined by light and electron microscopy. Evidence of neuroaxonal dystrophy (NAD) was found in young (3-mo.-old) mice and increased with age. Vitamin E, added to the diet in the amount of 0.3%, did not protect the nuclei from age-associated degeneration. The NAD was characterized by enlarged profiles containing patches of smooth reticular networks and groups of vesicles. Various stages of mitochondrial alteration, producing multivesicular bodies as intermediate stages, were found, and other unusual forms of dense bodies were also observed. Axons, synaptic terminals, and possibly glial cells were affected, and, by 23 mo. of age, a large number of nerve fibers in nucleus gracilis were dystrophic, while nucleus cuneatus was affected to a lesser extent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
395-411
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
A fine structural study of degenerative changes in the dorsal column nuclei of aging mice. Lack of protection by vitamin E.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.